InnateDB: Systems Biology of the Innate Immune Response

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81035122-81117432

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000321300	ENSP00000316338
ENST00000321280	ENSP00000315685
ENST00000428708	ENSP00000401022
ENST00000435091	ENSP00000413069
ENST00000416299	ENSP00000391837
ENST00000575712	ENSP00000458964
ENST00000574027
ENST00000576756	ENSP00000458440
ENST00000574688
ENST00000576364
ENST00000573894
ENST00000573659	ENSP00000461736
ENST00000572329	ENSP00000460492
ENST00000570913
ENST00000575750	ENSP00000460344
ENST00000575841	ENSP00000461101
ENST00000575989	ENSP00000458494
ENST00000576995
ENST00000572918	ENSP00000460131
ENST00000576225
ENST00000577097
ENST00000575245	ENSP00000461144
ENST00000575958	ENSP00000458522
ENST00000576470
ENST00000572498	ENSP00000460350
ENST00000573677	ENSP00000458735
ENST00000574804	ENSP00000459730
ENST00000572073	ENSP00000459787
ENST00000573017
ENST00000571530	ENSP00000458202

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0008286	insulin receptor signaling pathway
GO:0008360	regulation of cell shape
GO:0009617	response to bacterium
GO:0016358	dendrite development
GO:0032956	regulation of actin cytoskeleton organization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0046847	filopodium assembly
GO:0048167	regulation of synaptic plasticity
GO:0051017	actin filament bundle assembly
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030175	filopodium
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome