Version 5.4
Homo sapiens Gene: TNFAIP6
Summary
InnateDB Gene IDBG-72083.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP6
Gene Name tumor necrosis factor, alpha-induced protein 6
Synonyms TSG-6; TSG6
Species Homo sapiens
Ensembl Gene ENSG00000123610
Encoded Proteins
IDBP-72085
tumor necrosis factor, alpha-induced protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:151357592-151380048
Strand Forward strand
Band q23.3
Transcripts
ENST00000243347 ENSP00000243347
ENST00000460812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005540 hyaluronic acid binding
Biological Process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0030335 positive regulation of cell migration
GO:0030728 ovulation
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053475
View Gene Order
ENSBTAG00000007239
Not yet available
Cross-References
SwissProt P98066
TrEMBL
UniProt Splice Variant
Entrez Gene 7130
UniGene Hs.437322 Hs.615156
RefSeq NM_007115
HUGO HGNC:11898
OMIM 600410
CCDS CCDS2193
HPRD
IMGT
EMBL AC009311 AJ419936 AJ421518 BC030205 CH471058 M31165
GenPept AAB00792 AAH30205 AAY15067 CAD12353 CAD13434 EAX11511
RNA Seq Atlas 7130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca