InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACTG1

Summary

InnateDB Gene

IDBG-72264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTG1

Gene Name

actin, gamma 1

Synonyms

ACT; ACTG; BRWS1; BRWS2; DFNA20; DFNA26; HEL-176; PS1TP5BP1

Species

Homo sapiens

Ensembl Gene

ENSG00000184009

Encoded Proteins

IDBP-72266

actin, gamma 1

IDBP-762250

IDBP-764164

IDBP-762961

IDBP-758009

IDBP-761309

IDBP-760083

IDBP-758184

IDBP-764460

IDBP-757804

IDBP-759727

IDBP-812863

actin, gamma 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81509971-81523847

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000331925	ENSP00000331514
ENST00000576214
ENST00000570382	ENSP00000466346
ENST00000571721	ENSP00000460660
ENST00000574671
ENST00000573283	ENSP00000458435
ENST00000575994	ENSP00000460464
ENST00000575087	ENSP00000459124
ENST00000575659	ENSP00000459119
ENST00000571691	ENSP00000461407
ENST00000576917
ENST00000572105	ENSP00000462823
ENST00000576209
ENST00000575842	ENSP00000458162
ENST00000576544	ENSP00000461672
ENST00000615544	ENSP00000477968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.

Experimentally validated
Total	122 [view]
Protein-Protein	122 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042802	identical protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0006928	cellular component movement
GO:0007411	axon guidance
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0045214	sarcomere organization
GO:0045216	cell-cell junction organization
GO:0061024	membrane organization

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030016	myofibril
GO:0031941	filamentous actin
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle