Version 5.4
Homo sapiens Gene: APOA5
Summary
InnateDB Gene IDBG-72432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOA5
Gene Name apolipoprotein A-V
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110243
Encoded Proteins
IDBP-72436
apolipoprotein A-V
IDBP-383333
apolipoprotein A-V
IDBP-592467
apolipoprotein A-V
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:116789367-116792420
Strand Reverse strand
Band q23.3
Transcripts
ENST00000227665 ENSP00000227665
ENST00000433069 ENSP00000399701
ENST00000542499 ENSP00000445002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005543 phospholipid binding
GO:0008047 enzyme activator activity
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0019899 enzyme binding
GO:0031210 phosphatidylcholine binding
GO:0035473 lipase binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060229 lipase activator activity
GO:0060230 lipoprotein lipase activator activity
GO:0070325 lipoprotein particle receptor binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006869 lipid transport
GO:0009725 response to hormone
GO:0010898 positive regulation of triglyceride catabolic process
GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling
GO:0019433 triglyceride catabolic process
GO:0031100 organ regeneration
GO:0034370 triglyceride-rich lipoprotein particle remodeling
GO:0042157 lipoprotein metabolic process
GO:0042246 tissue regeneration
GO:0042632 cholesterol homeostasis
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050996 positive regulation of lipid catabolic process
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055090 acylglycerol homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032079
View Gene Order
ENSBTAG00000019764
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_6841
Chylomicron-mediated lipid transport pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JZZ0
UniProt Splice Variant
Entrez Gene 116519
UniGene Hs.283923
RefSeq NM_001166598 NM_052968 XM_006718761
HUGO HGNC:17288
OMIM 606368
CCDS CCDS8376
HPRD 06966
IMGT
EMBL AP006216
GenPept
RNA Seq Atlas 116519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca