Version 5.4
Homo sapiens Gene: UBQLN2
Summary
InnateDB Gene IDBG-72599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBQLN2
Gene Name ubiquilin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188021
Encoded Proteins
IDBP-72603
ubiquilin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:56563639-56567868
Strand Forward strand
Band p11.21
Transcripts
ENST00000338222 ENSP00000345195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 72 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006289 nucleotide-excision repair
GO:0008219 cell death
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050148
View Gene Order
ENSBTAG00000021843
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9UHD9
TrEMBL
UniProt Splice Variant
Entrez Gene 29978
UniGene Hs.179309 Hs.522668
RefSeq NM_013444
HUGO HGNC:12509
OMIM 300264
CCDS CCDS14374
HPRD
IMGT
EMBL AB015344 AF189009 AF293385 AL354793 AL442081 BC069237 CH471154
GenPept AAF17237 AAG02474 AAH69237 BAA34801 CAC09446 CAD13519 EAW93233
RNA Seq Atlas 29978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca