InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGDIA

Summary

InnateDB Gene

IDBG-72684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGDIA

Gene Name

Rho GDP dissociation inhibitor (GDI) alpha

Synonyms

GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1

Species

Homo sapiens

Ensembl Gene

ENSG00000141522

Encoded Proteins

IDBP-72686

Rho GDP dissociation inhibitor (GDI) alpha

IDBP-227541

Rho GDP dissociation inhibitor (GDI) alpha

IDBP-586940

Rho GDP dissociation inhibitor (GDI) alpha

IDBP-763127

IDBP-764502

IDBP-758432

IDBP-761936

IDBP-757796

IDBP-758818

IDBP-760525

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009]
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81867721-81871406

Strand

Reverse strand

Band

q25.3

Transcripts

ENST00000269321	ENSP00000269321
ENST00000400721	ENSP00000383556
ENST00000541078	ENSP00000441348
ENST00000582984
ENST00000581876	ENSP00000461956
ENST00000580033	ENSP00000463530
ENST00000584397
ENST00000578351	ENSP00000462323
ENST00000583499
ENST00000582309
ENST00000584461	ENSP00000463939
ENST00000583868	ENSP00000462209
ENST00000579121	ENSP00000462960
ENST00000580685	ENSP00000464205
ENST00000582520
ENST00000583111
ENST00000583791

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.

Experimentally validated
Total	101 [view]
Protein-Protein	99 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005094	Rho GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0007162	negative regulation of cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0030336	negative regulation of cell migration
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis
GO:0050772	positive regulation of axonogenesis
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0071526	semaphorin-plexin signaling pathway