InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NR4A2

Summary

InnateDB Gene

IDBG-72696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR4A2

Gene Name

nuclear receptor subfamily 4, group A, member 2

Synonyms

HZF-3; NOT; NURR1; RNR1; TINUR

Species

Homo sapiens

Ensembl Gene

ENSG00000153234

Encoded Proteins

IDBP-72698

nuclear receptor subfamily 4, group A, member 2

IDBP-293003

nuclear receptor subfamily 4, group A, member 2

IDBP-294010

nuclear receptor subfamily 4, group A, member 2

IDBP-294013

nuclear receptor subfamily 4, group A, member 2

IDBP-386684

nuclear receptor subfamily 4, group A, member 2

IDBP-386687

nuclear receptor subfamily 4, group A, member 2

IDBP-386688

nuclear receptor subfamily 4, group A, member 2

IDBP-386689

nuclear receptor subfamily 4, group A, member 2

IDBP-386694

nuclear receptor subfamily 4, group A, member 2

IDBP-386697

nuclear receptor subfamily 4, group A, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:156324432-156342348

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000339562	ENSP00000344479
ENST00000406048	ENSP00000385379
ENST00000409572	ENSP00000386747
ENST00000409108	ENSP00000386993
ENST00000426264	ENSP00000389986
ENST00000417972	ENSP00000394671
ENST00000417764	ENSP00000415632
ENST00000429376	ENSP00000410952
ENST00000424077	ENSP00000406808
ENST00000421709	ENSP00000388120

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	15 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001764	neuron migration
GO:0001975	response to amphetamine
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0008344	adult locomotory behavior
GO:0009791	post-embryonic development
GO:0010035	response to inorganic substance
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0016265	death
GO:0017085	response to insecticide
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021953	central nervous system neuron differentiation
GO:0021986	habenula development
GO:0030182	neuron differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0034599	cellular response to oxidative stress
GO:0042053	regulation of dopamine metabolic process
GO:0042416	dopamine biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042551	neuron maturation
GO:0043085	positive regulation of catalytic activity
GO:0043401	steroid hormone mediated signaling pathway
GO:0043524	negative regulation of neuron apoptotic process
GO:0043576	regulation of respiratory gaseous exchange
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051866	general adaptation syndrome
GO:0071542	dopaminergic neuron differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026826

View Gene Order

ENSBTAG00000003650

Not yet available

Pathways

NETPATH

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.165258 Hs.563344

RefSeq

NM_006186 XM_005246621 XM_005246623

HUGO

OMIM

CCDS

CCDS2201

HPRD

03493

IMGT

EMBL

GenPept

RNA Seq Atlas