Homo sapiens Gene: CALR3
Summary
InnateDB Gene IDBG-728300.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALR3
Gene Name calreticulin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000269058
Encoded Proteins
calreticulin 3
Protein Structure
Entrez Gene
Summary The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16479057-16496192
Strand Reverse strand
Band p13.11
Transcripts
ENST00000269881 ENSP00000269881
ENST00000602234
ENST00000600762 ENSP00000471533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044183 protein binding involved in protein folding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q96L12
TrEMBL
UniProt Splice Variant
Entrez Gene 125972
UniGene Hs.304020
RefSeq NM_145046
HUGO HGNC:20407
OMIM 611414
CCDS CCDS12344
HPRD 12999
IMGT
EMBL AB576176 AC008764 AK058084 BC014595 CH471106
GenPept AAH14595 BAB71655 BAJ14705 EAW84546
ImmGen CALR3 (murine)
RNA Seq Atlas 125972