Homo sapiens Gene: CALR3

Summary
InnateDB Gene IDBG-728300.1
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol CALR3
Gene Name calreticulin 3
Synonyms CMH19; CRT2; CT93
Species Homo sapiens
Ensembl Gene ENSG00000269058
Encoded Proteins
IDBP-35570 calreticulin 3
IDBP-764881
Entrez Gene
Summary The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 16589868-16607003
Strand Reverse strand
Band p13.11
Transcripts
ENST00000269881  ENSP00000269881
ENST00000602234 
ENST00000600762  ENSP00000471533
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  1
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005509 calcium ion binding
GO:0030246 carbohydrate binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96L12 
TrEMBL
UniProt Splice Variant
Entrez Gene 125972 
UniGene Hs.304020
RefSeq NM_145046 
HUGO 20407 
OMIM 611414
CCDS CCDS12344 
HPRD 12999
IMGT
EMBL AB576176 AC008764 AK058084 BC014595 CH471106
GenPept AAH14595  BAB71655  BAJ14705  EAW84546 
ImmGen CALR3 (murine) 
RNA Seq Atlas 125972