Version 5.4
Homo sapiens Gene: SIRT7
Summary
InnateDB Gene IDBG-72839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT7
Gene Name sirtuin 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187531
Encoded Proteins
IDBP-72841
sirtuin 7
IDBP-759047
IDBP-759935
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:81911939-81921323
Strand Reverse strand
Band q25.3
Transcripts
ENST00000328666 ENSP00000329466
ENST00000536038
ENST00000571915
ENST00000572902 ENSP00000461044
ENST00000575244
ENST00000572976
ENST00000573367
ENST00000574495
ENST00000571233
ENST00000575360 ENSP00000459524
ENST00000572350
ENST00000576156
ENST00000572671
ENST00000574915
ENST00000574992
ENST00000571832
ENST00000571213
ENST00000574153
ENST00000577065
ENST00000570367
ENST00000573576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 663 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 663 [view]
Protein-Protein 663 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0070403 NAD+ binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007072 positive regulation of transcription on exit from mitosis
GO:0009303 rRNA transcription
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0005730 nucleolus
GO:0005731 nucleolus organizer region
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025138
View Gene Order
ENSBTAG00000000039
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514636
RefSeq NM_016538
HUGO
OMIM
CCDS CCDS11792
HPRD 12094
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca