Homo sapiens Gene: TGIF2 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-72851.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | TGIF2 | ||||||||||||||||||||
Gene Name | TGFB-induced factor homeobox 2 | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000118707 | ||||||||||||||||||||
Encoded Proteins |
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
TGFB-induced factor homeobox 2
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 20:36573488-36593950 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | q11.23 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||||
Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Generic Transcription Pathway pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
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KEGG | |||||||||||||||||||||
INOH | |||||||||||||||||||||
PID NCI |
Regulation of nuclear SMAD2/3 signaling
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 60436 | ||||||||||||||||||||
UniGene | |||||||||||||||||||||
RefSeq | NM_001199513 NM_001199514 NM_001199515 NM_021809 | ||||||||||||||||||||
HUGO | HGNC:15764 | ||||||||||||||||||||
OMIM | 607294 | ||||||||||||||||||||
CCDS | CCDS13278 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | |||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | 60436 | ||||||||||||||||||||