Version 5.4
| Homo sapiens Gene: SIGLEC5 | |||||
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| Summary | |||||
| InnateDB Gene | IDBG-728530.2 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | SIGLEC5 | ||||
| Gene Name | Sialic acid-binding Ig-like lectin 5 | ||||
| Synonyms | CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5 | ||||
| Species | Homo sapiens | ||||
| Ensembl Gene | ENSG00000268500 | ||||
| Encoded Proteins |
sialic acid binding Ig-like lectin 5
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| Protein Structure | |||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||
| Entrez Gene | |||||
| Summary |
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
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| Gene Information | |||||
| Type | Protein coding | ||||
| Genomic Location | Chromosome 19:51612091-51646889 | ||||
| Strand | Reverse strand | ||||
| Band | q13.41 | ||||
| Transcripts |
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| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||
| No orthologs found for this gene | |||||
| Cross-References | |||||
| SwissProt | |||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | |||||
| UniGene | Hs.628360 | ||||
| RefSeq | |||||
| HUGO | |||||
| OMIM | |||||
| CCDS | |||||
| HPRD | |||||
| IMGT | |||||
| EMBL | |||||
| GenPept | |||||
| RNA Seq Atlas | |||||