Homo sapiens Gene: PYCR1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-72880.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PYCR1 | ||||||||||||||||||
Gene Name | pyrroline-5-carboxylate reductase 1 | ||||||||||||||||||
Synonyms | ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000183010 | ||||||||||||||||||
Encoded Proteins |
pyrroline-5-carboxylate reductase 1
pyrroline-5-carboxylate reductase 1
pyrroline-5-carboxylate reductase 1
pyrroline-5-carboxylate reductase 1
pyrroline-5-carboxylate reductase 1
pyrroline-5-carboxylate reductase 1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 17:81932384-81942412 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q25.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Amino acid synthesis and interconversion (transamination) pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
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KEGG |
Arginine and proline metabolism pathway
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INOH |
Arginine Proline metabolism pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.163451 | ||||||||||||||||||
RefSeq | NM_001282279 NM_001282280 NM_001282281 NM_006907 NM_153824 XM_005256381 XM_006722286 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS11794 CCDS11795 CCDS62365 CCDS62366 | ||||||||||||||||||
HPRD | 01528 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||