Homo sapiens Gene: null
Summary
InnateDB Gene IDBG-728893.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol null
Gene Name G protein pathway suppressor 2
Synonyms AMF-1;
Species Homo sapiens
Ensembl Gene ENSG00000261915
Encoded Proteins
Protein Structure
Entrez Gene
Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7312661-7319174
Strand Reverse strand
Band p13.1
Transcripts
ENST00000315601 ENSP00000468744
ENST00000575474 ENSP00000468772
ENST00000573651 ENSP00000467514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL K7EPS7
UniProt Splice Variant
Entrez Gene 84461
UniGene
RefSeq NM_001005408 NM_032442
HUGO HGNC:34410 HGNC:4550
OMIM 601935 615865
CCDS CCDS42251 CCDS42252
HPRD
IMGT
EMBL AC026954
GenPept
ImmGen null (murine)
RNA Seq Atlas 2874 84461