Homo sapiens Gene: null
Summary
InnateDB Gene IDBG-728893.1
Last Modified 2013-04-25 [Report errors or provide feedback]
Gene Symbol null
Gene Name G protein pathway suppressor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000261915
Encoded Proteins
Protein Structure
Entrez Gene
Summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7215980-7230158
Strand Reverse strand
Band p13.1
Transcripts
ENST00000315601 ENSP00000468744
ENST00000575474 ENSP00000468772
ENST00000573651 ENSP00000467514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2874
UniGene
RefSeq NM_004489
HUGO
OMIM 601935
CCDS
HPRD
IMGT
EMBL
GenPept
ImmGen null (murine)
RNA Seq Atlas 2874