InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAFAH1B2

Summary

InnateDB Gene

IDBG-73009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAFAH1B2

Gene Name

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

Synonyms

HEL-S-303

Species

Homo sapiens

Ensembl Gene

ENSG00000168092

Encoded Proteins

IDBP-73011

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

IDBP-383433

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

IDBP-586253

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

IDBP-602357

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

IDBP-587784

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [providedby RefSeq, May 2010]
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:117144267-117176894

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000304808	ENSP00000304006
ENST00000419197	ENSP00000388742
ENST00000527958	ENSP00000435289
ENST00000529887	ENSP00000434951
ENST00000526888
ENST00000530272	ENSP00000431365
ENST00000533206
ENST00000533677

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007283	spermatogenesis
GO:0007420	brain development
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0016239	positive regulation of macroautophagy

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003131

View Gene Order

ENSBTAG00000005627

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00565

Ether lipid metabolism pathway

INOH

PID NCI

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

P68402

TrEMBL

UniProt Splice Variant

Entrez Gene

5049

UniGene

Hs.728488 Hs.743251

RefSeq

NM_001184746 NM_001184747 NM_001184748 NM_002572

HUGO

HGNC:8575

OMIM

602508

CCDS

CCDS53714 CCDS53713 CCDS53715 CCDS8380

HPRD

03940

IMGT

EMBL

AK292973 AP005018 BC000398 BC019301 CH471065 CR456736 D63390 DQ836738 DQ836739 DQ836740 DQ836741 DQ836742 DQ836743 EF445007

GenPept

AAH00398 AAH19301 ABI58225 ABI58226 ABI58227 ABI58228 ABI58229 ABI58230 ACA06040 BAA19917 BAF85662 CAG33017 EAW67281

RNA Seq Atlas

5049