Version 5.4
Homo sapiens Gene: GPS1
Summary
InnateDB Gene IDBG-73152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPS1
Gene Name G protein pathway suppressor 1
Synonyms COPS1; CSN1
Species Homo sapiens
Ensembl Gene ENSG00000169727
Encoded Proteins
IDBP-73156
G protein pathway suppressor 1
IDBP-73158
G protein pathway suppressor 1
IDBP-245826
G protein pathway suppressor 1
IDBP-759356
IDBP-759076
IDBP-759645
IDBP-761122
IDBP-759026
IDBP-764766
IDBP-760339
IDBP-764065
IDBP-764664
IDBP-763874
IDBP-762923
IDBP-761948
IDBP-761579
IDBP-761634
IDBP-759570
IDBP-764796
IDBP-813770
G protein pathway suppressor 1
IDBP-813771
G protein pathway suppressor 1
IDBP-813772
G protein pathway suppressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:82050691-82057470
Strand Forward strand
Band q25.3
Transcripts
ENST00000306823 ENSP00000302873
ENST00000320548 ENSP00000313569
ENST00000392358 ENSP00000376167
ENST00000392357
ENST00000580141 ENSP00000464530
ENST00000583641 ENSP00000462029
ENST00000580716 ENSP00000463690
ENST00000583009 ENSP00000463514
ENST00000583486
ENST00000583961 ENSP00000463381
ENST00000583983
ENST00000582327 ENSP00000464575
ENST00000585084 ENSP00000462391
ENST00000578168 ENSP00000463937
ENST00000578279
ENST00000583885 ENSP00000461965
ENST00000578392 ENSP00000462705
ENST00000580627 ENSP00000463823
ENST00000581418 ENSP00000462896
ENST00000584460 ENSP00000462297
ENST00000580723 ENSP00000462213
ENST00000581578 ENSP00000464571
ENST00000578552 ENSP00000462265
ENST00000578642
ENST00000584229
ENST00000624957 ENSP00000485641
ENST00000623691 ENSP00000485330
ENST00000623761 ENSP00000485035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025156
View Gene Order
ENSBTAG00000019317
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004127 NM_212492 XM_005256356 XM_005256357 XM_005256358 XM_005256362 XM_005256363
HUGO
OMIM
CCDS CCDS11800 CCDS32774
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca