InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM28

Summary

InnateDB Gene

IDBG-73191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM28

Gene Name

tripartite motif containing 28

Synonyms

KAP1; PPP1R157; RNF96; TF1B; TIF1B

Species

Homo sapiens

Ensembl Gene

ENSG00000130726

Encoded Proteins

IDBP-73193

tripartite motif containing 28

IDBP-73195

tripartite motif containing 28

IDBP-761118

IDBP-764359

IDBP-760799

IDBP-765105

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22995936

TRIM28 interacts with IRF5 and mediates heterochromatinization at M1 macrophage markers (e.g. TNF) to suppress transcription.

Entrez Gene

Summary

The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:58544091-58550722

Strand

Forward strand

Band

q13.43

Transcripts

ENST00000253024	ENSP00000253024
ENST00000341753	ENSP00000342232
ENST00000597423
ENST00000598355
ENST00000597995
ENST00000595028
ENST00000595974
ENST00000597618
ENST00000593582	ENSP00000472586
ENST00000601150
ENST00000597968	ENSP00000470503
ENST00000600840
ENST00000594806	ENSP00000473126
ENST00000597172
ENST00000597136	ENSP00000471303

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 271 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	271 [view]
Protein-Protein	271 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0035851	Krueppel-associated box domain binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001837	epithelial to mesenchymal transition
GO:0006281	DNA repair
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0010467	gene expression
GO:0016567	protein ubiquitination
GO:0016925	protein sumoylation
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0045739	positive regulation of DNA repair
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046777	protein autophosphorylation
GO:0051259	protein oligomerization
GO:0060028	convergent extension involved in axis elongation
GO:0060669	embryonic placenta morphogenesis
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0000785	chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005566

View Gene Order

ENSBTAG00000006422

Not yet available

Pathways

NETPATH

REACTOME

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

p53regulationpathway

p53 pathway

cmyb_pathway

C-MYB transcription factor network

e2f_pathway

E2F transcription factor network

atm_pathway

ATM pathway

Cross-References

SwissProt

Q13263

TrEMBL

M0QZE6 M0R0K9 M0R2I3 M0R3C0

UniProt Splice Variant

Entrez Gene

10155

UniGene

Hs.467408

RefSeq

NM_005762

HUGO

HGNC:16384

OMIM

601742

CCDS

CCDS12985

HPRD

IMGT

EMBL

AC016630 BC004978 BC007390 BC052986 U31657 U78773 U95040 X97548

GenPept

AAA74954 AAB37341 AAB51517 AAH04978 AAH07390 AAH52986 CAA66150

RNA Seq Atlas

10155