Homo sapiens Gene: PTPN20B

Summary
InnateDB Gene IDBG-73212.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PTPN20B
Gene Name protein tyrosine phosphatase, non-receptor type 20B
Synonyms bA42B19.1
Species Homo sapiens
Ensembl Gene ENSG00000183675
Encoded Proteins
IDBP-73214 protein tyrosine phosphatase, non-receptor type 20B
IDBP-73216 protein tyrosine phosphatase, non-receptor type 20B
IDBP-73222 protein tyrosine phosphatase, non-receptor type 20B
IDBP-73224 protein tyrosine phosphatase, non-receptor type 20B
IDBP-239037 protein tyrosine phosphatase, non-receptor type 20B
IDBP-239039 protein tyrosine phosphatase, non-receptor type 20B
IDBP-239041 protein tyrosine phosphatase, non-receptor type 20B
IDBP-239043 protein tyrosine phosphatase, non-receptor type 20B
IDBP-239045 protein tyrosine phosphatase, non-receptor type 20B
IDBP-374709 protein tyrosine phosphatase, non-receptor type 20B
IDBP-475310 protein tyrosine phosphatase, non-receptor type 20B
IDBP-484658 protein tyrosine phosphatase, non-receptor type 20B
IDBP-479579 protein tyrosine phosphatase, non-receptor type 20B
IDBP-481507 protein tyrosine phosphatase, non-receptor type 20B
IDBP-476243 protein tyrosine phosphatase, non-receptor type 20B
IDBP-481758 protein tyrosine phosphatase, non-receptor type 20B
IDBP-475478 protein tyrosine phosphatase, non-receptor type 20B
IDBP-477140 protein tyrosine phosphatase, non-receptor type 20B
IDBP-479425 protein tyrosine phosphatase, non-receptor type 20B
IDBP-484463 protein tyrosine phosphatase, non-receptor type 20B
IDBP-479955 protein tyrosine phosphatase, non-receptor type 20B
IDBP-473504 protein tyrosine phosphatase, non-receptor type 20B
IDBP-481930 protein tyrosine phosphatase, non-receptor type 20B
IDBP-479495 protein tyrosine phosphatase, non-receptor type 20B
IDBP-479146 protein tyrosine phosphatase, non-receptor type 20B
Entrez Gene
Summary The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more centromeric copy, PTPN20A. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10: 48736874-48827966
Strand Reverse strand
Band q11.22
Transcripts
ENST00000331650  ENSP00000331832
ENST00000374240  ENSP00000363357
ENST00000374237 
ENST00000374235  ENSP00000363352
ENST00000374233  ENSP00000363350
ENST00000395674  ENSP00000379033
ENST00000395668  ENSP00000379027
ENST00000395662  ENSP00000379022
ENST00000395661  ENSP00000379021
ENST00000395660  ENSP00000379020
ENST00000417914  ENSP00000406097
ENST00000504747 
ENST00000509544 
ENST00000514592  ENSP00000423839
ENST00000513933  ENSP00000427171
ENST00000505714 
ENST00000515532  ENSP00000422953
ENST00000507329 
ENST00000514491  ENSP00000424942
ENST00000509230  ENSP00000421604
ENST00000509631  ENSP00000424344
ENST00000510840  ENSP00000423545
ENST00000512924  ENSP00000421999
ENST00000509753  ENSP00000425285
ENST00000511387  ENSP00000426298
ENST00000502266  ENSP00000424728
ENST00000507417  ENSP00000425723
ENST00000503086 
ENST00000512321  ENSP00000427588
ENST00000507697  ENSP00000426605
ENST00000472263 
ENST00000510141  ENSP00000427081
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q4JDL3 
TrEMBL D6RC68 D6RFJ1 G8JLF7 G8JLF9 Q4JDK3 Q5T1G4
UniProt Splice Variant
Entrez Gene 26095  653129 
UniGene Hs.499552
RefSeq NM_001042357  NM_001042358  NM_001042359  NM_001042360  NM_001042361  NM_001042362  NM_001042363  NM_001042364  NM_001042397  NM_015605 
HUGO 23423 
OMIM 610630 610631
CCDS CCDS41512  CCDS41513  CCDS41514  CCDS41515  CCDS41516  CCDS53533  CCDS53534  CCDS53535  CCDS7221 
HPRD 10898
IMGT
EMBL AL358791 AL450334 AL672108 AY704141 AY704142 AY704143 AY704144 AY704145 AY704146 AY704147 AY704148 AY704149 AY704150 AY704151 AY704152 AY704153 AY704154 AY704155 AY704156 AY704157 AY704158 AY753191 BC093750 BC113473 BC143394 BC171725 BX005072
GenPept AAH93750  AAI13474  AAI43395  AAI71725  AAW28780  AAW28781  AAW28782  AAW28783  AAW28784  AAW28785  AAW28786  AAW28787  AAW28788  AAW28789  AAW28790  AAW28791  AAW28792  AAW28793  AAW28794  AAW28795  AAW28796  AAW28797  AAW88572  CAI12199  CAI12200  CAI14088  CAI14089  CAI14090  CAI15684  CAI15685  CAI23640  CAI23642 
ImmGen PTPN20B (murine) 
RNA Seq Atlas 26095  653129