Homo sapiens Gene: PTPN20B
Summary
InnateDB Gene IDBG-73212.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PTPN20B
Gene Name protein tyrosine phosphatase, non-receptor type 20B
Synonyms bA42B19.1;
Species Homo sapiens
Ensembl Gene ENSG00000183675
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20B
Protein Structure
Entrez Gene
Summary The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more centromeric copy, PTPN20A. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes and several are mutated in human diseases. Chromosome 10q contains a segmental duplication resulting in multiple copies of the protein tyrosine phosphatase, non-receptor type 20 gene. The two nearly identical copies are designated as PTPN20A and PTPN20B. A third copy is only partially duplicated and contains a pseudogene, designated as PTPN20C. This gene encodes the more telomeric copy, PTPN20B. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:48736874-48827966
Strand Reverse strand
Band q11.22
Transcripts
ENST00000331650 ENSP00000331832
ENST00000374240 ENSP00000363357
ENST00000374237
ENST00000374235 ENSP00000363352
ENST00000374233 ENSP00000363350
ENST00000395674 ENSP00000379033
ENST00000395668 ENSP00000379027
ENST00000395662 ENSP00000379022
ENST00000395661 ENSP00000379021
ENST00000395660 ENSP00000379020
ENST00000417914 ENSP00000406097
ENST00000504747
ENST00000509544
ENST00000514592 ENSP00000423839
ENST00000513933 ENSP00000427171
ENST00000505714
ENST00000515532 ENSP00000422953
ENST00000507329
ENST00000514491 ENSP00000424942
ENST00000509230 ENSP00000421604
ENST00000509631 ENSP00000424344
ENST00000510840 ENSP00000423545
ENST00000512924 ENSP00000421999
ENST00000509753 ENSP00000425285
ENST00000511387 ENSP00000426298
ENST00000502266 ENSP00000424728
ENST00000507417 ENSP00000425723
ENST00000503086
ENST00000512321 ENSP00000427588
ENST00000507697 ENSP00000426605
ENST00000472263
ENST00000510141 ENSP00000427081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q4JDL3
TrEMBL D6RC68 D6RFJ1 G8JLF7 G8JLF9 Q4JDK3 Q5T1G4
UniProt Splice Variant
Entrez Gene 653129
UniGene Hs.499552
RefSeq NM_001042357 NM_001042358 NM_001042359 NM_001042360 NM_001042361 NM_001042362 NM_001042363 NM_001042364 NM_001042397 NM_015605
HUGO 23423
OMIM 610630 610631
CCDS CCDS41512 CCDS41513 CCDS41514 CCDS41515 CCDS41516 CCDS53533 CCDS53534 CCDS53535 CCDS7221
HPRD 10898
IMGT
EMBL AL358791 AL450334 AL672108 AY704141 AY704142 AY704143 AY704144 AY704145 AY704146 AY704147 AY704148 AY704149 AY704150 AY704151 AY704152 AY704153 AY704154 AY704155 AY704156 AY704157 AY704158 AY753191 BC093750 BC113473 BC143394 BC171725 BX005072
GenPept AAH93750 AAI13474 AAI43395 AAI71725 AAW28780 AAW28781 AAW28782 AAW28783 AAW28784 AAW28785 AAW28786 AAW28787 AAW28788 AAW28789 AAW28790 AAW28791 AAW28792 AAW28793 AAW28794 AAW28795 AAW28796 AAW28797 AAW88572 CAI12199 CAI12200 CAI14088 CAI14089 CAI14090 CAI15684 CAI15685 CAI23640 CAI23642
ImmGen PTPN20B (murine)
RNA Seq Atlas 26095 653129