Homo sapiens Gene: PLA2G6

Summary
InnateDB Gene IDBG-7325.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PLA2G6
Gene Name phospholipase A2, group VI (cytosolic, calcium-independent)
Synonyms CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9
Species Homo sapiens
Ensembl Gene ENSG00000184381
Encoded Proteins
IDBP-7327 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-7331 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-293649 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376373 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376408 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376411 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376416 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376422 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376424 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376427 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376431 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376433 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376437 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376442 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376444 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376446 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-376449 phospholipase A2, group VI (cytosolic, calcium-independent)
IDBP-719834
IDBP-719840
Entrez Gene
Summary The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22: 38507502-38601697
Strand Reverse strand
Band q13.1
Transcripts
ENST00000332509  ENSP00000333142
ENST00000335539  ENSP00000335149
ENST00000402064  ENSP00000386100
ENST00000419848  ENSP00000412061
ENST00000454670  ENSP00000413145
ENST00000448094  ENSP00000407106
ENST00000452794  ENSP00000392968
ENST00000451461  ENSP00000405613
ENST00000427114  ENSP00000407743
ENST00000427453  ENSP00000408298
ENST00000452542  ENSP00000412629
ENST00000430886  ENSP00000395464
ENST00000436218  ENSP00000401242
ENST00000445591 
ENST00000452972 
ENST00000447598  ENSP00000393361
ENST00000435484  ENSP00000413597
ENST00000417303  ENSP00000404974
ENST00000455341  ENSP00000393761
ENST00000420435 
ENST00000426674 
ENST00000463287 
ENST00000496409 
ENST00000491986 
ENST00000490473 
ENST00000471636 
ENST00000480154 
ENST00000498338  ENSP00000472058
ENST00000479641 
ENST00000594306  ENSP00000473160
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein‑Protein  3
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0016787 hydrolase activity
GO:0043008 ATP-dependent protein binding
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006935 chemotaxis
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0007613 memory
GO:0008152 metabolic process
GO:0008219 cell death
GO:0014832 urinary bladder smooth muscle contraction
GO:0016042 lipid catabolic process
GO:0032049 cardiolipin biosynthetic process
GO:0034976 response to endoplasmic reticulum stress
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035965 cardiolipin acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0045909 positive regulation of vasodilation
GO:0045921 positive regulation of exocytosis
GO:0046474 glycerophospholipid biosynthetic process
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0090037 positive regulation of protein kinase C signaling cascade
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090238 positive regulation of arachidonic acid secretion
GO:1901339 regulation of store-operated calcium channel activity
GO:2000304 positive regulation of ceramide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000042632 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000014015 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_121006 Acyl chain remodeling of CL
REACT_160158 Role of phospholipids in phagocytosis
KEGG
hsa00592  Alpha-Linolenic acid metabolism
hsa00590  Arachidonic acid metabolism
hsa00565  Ether lipid metabolism
hsa04975  Fat digestion and absorption
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa00564  Glycerophospholipid metabolism
hsa04912  GnRH signaling pathway
hsa00591  Linoleic acid metabolism
hsa04730  Long-term depression
hsa04010  MAPK signaling pathway
hsa01100  Metabolic pathways
hsa04972  Pancreatic secretion
hsa05145  Toxoplasmosis
hsa04370  VEGF signaling pathway
hsa04270  Vascular smooth muscle contraction
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O60733 
TrEMBL B0QYE3 B0QYE4 B0QYE5 B0QYE6 B0QYE9 B7Z6K3 E7EN23 E7EX67 F2Z3G2 F8WEN3 F8WEQ9
UniProt Splice Variant
Entrez Gene 8398 
UniGene Hs.170479 Hs.641914
RefSeq NM_001004426  NM_001199562  NM_003560 
HUGO 9039 
OMIM 603604
CCDS CCDS13967  CCDS33645 
HPRD 04675
IMGT
EMBL AF064594 AF102988 AF102989 AF116252 AF116253 AF116254 AF116255 AF116256 AF116257 AF116258 AF116259 AF116260 AF116261 AF116262 AF116263 AF116264 AF116265 AF116266 AF116267 AF117677 AF117678 AF117679 AF117680 AF117681 AF117682 AF117683 AF117684 AF117685 AF117686 AF117687 AF117688 AF117689 AF117690 AF117691 AF117692 AK291212 AK300459 AL021977 AL022322 AL080187 AY522921 BC036742 BC051904 CH471095 CR456543
GenPept AAC97486  AAD30424  AAD41722  AAD41723  AAF34728  AAH36742  AAH51904  AAR92478  BAF83901  BAH13289  CAA18446  CAB45768  CAG30429  CAQ10441  CAQ10442  CAQ10443  CAQ10444  CAQ10446  CAQ10447  EAW60219  EAW60220 
ImmGen PLA2G6 (murine) 
RNA Seq Atlas 8398