Version 5.4
Homo sapiens Gene: MAPK8
Summary
InnateDB Gene IDBG-73479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK8
Gene Name mitogen-activated protein kinase 8
Synonyms JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Species Homo sapiens
Ensembl Gene ENSG00000107643
Encoded Proteins
IDBP-73481
mitogen-activated protein kinase 8
IDBP-73483
mitogen-activated protein kinase 8
IDBP-73485
mitogen-activated protein kinase 8
IDBP-73487
mitogen-activated protein kinase 8
IDBP-73489
mitogen-activated protein kinase 8
IDBP-73491
mitogen-activated protein kinase 8
IDBP-239200
mitogen-activated protein kinase 8
IDBP-375000
mitogen-activated protein kinase 8
IDBP-375002
mitogen-activated protein kinase 8
IDBP-375013
mitogen-activated protein kinase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19153595
MAPK8 phosphorylates IRF3 and is essential for IRF3 dimerization induced by polyinosinic-cytidylic acid (polyI:C).
PMID 25642820
Mycobacterium tuberculosis phosphatase PtpA suppresses innate immunity by binding to ubiquitin; which, in turn, activates it to dephosphorylate phosphorylated MAPK8 and MAPK14.
InnateDB Annotation from Orthologs
Summary
PMID 24185614
[Mus musculus] Phosphorylation of the inflammasome adaptor Pycard (ASC) controls inflammasome activity through the formation of ASC specks. The NLRP3 and AIM2 inflammasomes require Syk and Mapk8 (JNK) for their full activity .
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:48306639-48439360
Strand Forward strand
Band q11.22
Transcripts
ENST00000374189 ENSP00000363304
ENST00000374182 ENSP00000363297
ENST00000374179 ENSP00000363294
ENST00000360332 ENSP00000353483
ENST00000374176 ENSP00000363291
ENST00000374174 ENSP00000363289
ENST00000395611 ENSP00000378974
ENST00000432379 ENSP00000387936
ENST00000429041 ENSP00000393223
ENST00000426557 ENSP00000397729
ENST00000476134
ENST00000469879
ENST00000471272
ENST00000469110
ENST00000482840
ENST00000459755
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 259 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 259 [view]
Protein-Protein 255 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035033 histone deacetylase regulator activity
GO:0042826 histone deacetylase binding
Biological Process
GO:0000165 MAPK cascade
GO:0001503 ossification
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009411 response to UV
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0031063 regulation of histone deacetylation
GO:0032091 negative regulation of protein binding
GO:0032880 regulation of protein localization
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0046686 response to cadmium ion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071732 cellular response to nitric oxide
GO:0090045 positive regulation of deacetylase activity
GO:0097190 apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000017 positive regulation of determination of dorsal identity
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000021936
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_24
TSLP pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_21368
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_13643
NRIF signals cell death from the nucleus pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_1650
Activation of BIM and translocation to mitochondria pathway
REACT_2100
Activation of BMF and translocation to mitochondria pathway
REACT_25299
DSCAM interactions pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_111155
Cell-Cell communication pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05212
Pancreatic cancer pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
PDGF signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
ceramide_pathway
Ceramide signaling pathway
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
reelinpathway
Reelin signaling pathway
il1pathway
IL1-mediated signaling events
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
s1p_s1p2_pathway
S1P2 pathway
trail_pathway
TRAIL signaling pathway
atf2_pathway
ATF-2 transcription factor network
epopathway
EPO signaling pathway
reg_gr_pathway
Glucocorticoid receptor regulatory network
rac1_pathway
RAC1 signaling pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
ephrinbrevpathway
Ephrin B reverse signaling
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
cdc42_pathway
CDC42 signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
rhoa_pathway
RhoA signaling pathway
ar_tf_pathway
Regulation of Androgen receptor activity
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
ncadherinpathway
N-cadherin signaling events
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.138211 Hs.522924 Hs.732005 Hs.738804
RefSeq NM_001278547 NM_001278548 NM_002750 NM_139046 NM_139049 XM_006717917 XM_006717918 XM_006717919
HUGO
OMIM
CCDS CCDS60527 CCDS7223 CCDS7224 CCDS7225 CCDS7226
HPRD 03100
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca