Version 5.4
Homo sapiens Gene: MPZL2
Summary
InnateDB Gene IDBG-73587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPZL2
Gene Name myelin protein zero-like 2
Synonyms EVA; EVA1
Species Homo sapiens
Ensembl Gene ENSG00000149573
Encoded Proteins
IDBP-73589
myelin protein zero-like 2
IDBP-383646
myelin protein zero-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:118253403-118264536
Strand Reverse strand
Band q23.3
Transcripts
ENST00000278937 ENSP00000278937
ENST00000438295 ENSP00000408362
ENST00000528554
ENST00000534175
ENST00000529376
ENST00000527282
ENST00000525647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0009653 anatomical structure morphogenesis
GO:0016337 single organismal cell-cell adhesion
GO:0033077 T cell differentiation in thymus
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032092
View Gene Order
ENSBTAG00000033510
Not yet available
Cross-References
SwissProt O60487
TrEMBL A0A024R3K1
UniProt Splice Variant
Entrez Gene 10205
UniGene Hs.116651 Hs.621704
RefSeq NM_005797 NM_144765
HUGO HGNC:3496
OMIM 604873
CCDS CCDS8393
HPRD
IMGT
EMBL AF030455 AF275945 AF304447 AK290326 AY359061 BC017774 CH471065
GenPept AAC39762 AAF87240 AAG23183 AAH17774 AAQ89420 BAF83015 EAW67358 EAW67359
RNA Seq Atlas 10205

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca