InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBQLN1

Summary

InnateDB Gene

IDBG-73620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBQLN1

Gene Name

ubiquilin 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000135018

Encoded Proteins

IDBP-73622

ubiquilin 1

IDBP-73624

ubiquilin 1

IDBP-596675

ubiquilin 1

IDBP-585512

ubiquilin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21695056

UBQLN1 strongly suppresses the transcriptional activation of the IFNB promoter and is an inhibitor of the TLR3/TICAM1 anti-viral pathway by reducing TICAM1 protein levels.

InnateDB Annotation from Orthologs

Summary

PMID 21695056

[Mus musculus] Ubqln1 strongly suppresses the transcriptional activation of Ifnb promoter and is an inhibitor of the Tlr3/Ticam1 anti-viral pathway by reducing Ticam1 protein levels. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:83659963-83708203

Strand

Reverse strand

Band

q21.32

Transcripts

ENST00000376395	ENSP00000365576
ENST00000257468	ENSP00000257468
ENST00000533705
ENST00000526134	ENSP00000436912
ENST00000527373
ENST00000529923	ENSP00000434194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 360 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	360 [view]
Protein-Protein	356 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0031396	regulation of protein ubiquitination
GO:0034976	response to endoplasmic reticulum stress
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005312

View Gene Order

ENSBTAG00000014827

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

cxcr4_pathway

CXCR4-mediated signaling events

Cross-References

SwissProt

TrEMBL

H0YDS0

UniProt Splice Variant

Entrez Gene

29979

UniGene

Hs.9589

RefSeq

NM_013438 NM_053067

HUGO

HGNC:12508

OMIM

605046

CCDS

CCDS6663 CCDS6664

HPRD

05440

IMGT

EMBL

AL354920

GenPept

RNA Seq Atlas

29979