Version 5.4
Homo sapiens Gene: MYZAP
Summary
InnateDB Gene IDBG-736327.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYZAP
Gene Name myocardial zonula adherens protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000263155
Encoded Proteins
IDBP-13756
GRINL1A complex locus
IDBP-13758
GRINL1A complex locus
IDBP-593284
GRINL1A complex locus
IDBP-745867
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is abundantly expressed in cardiac tissue. The encoded protein localizes to intercalated discs in cardiomyocytes and functions as an activator of Rho-dependent serum-response factor signaling. Alternate splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstreamstream gene POLR2M (polymerase (RNA) II (DNA directed) polypeptide M). [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:57591941-57685364
Strand Forward strand
Band q21.3
Transcripts
ENST00000267853 ENSP00000267853
ENST00000380565 ENSP00000369939
ENST00000461709 ENSP00000431396
ENST00000569089 ENSP00000457126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030864 cortical actin cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031674 I band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041361
View Gene Order
ENSBTAG00000002194
Not yet available
Cross-References
SwissProt
TrEMBL H3BTD5
UniProt Splice Variant
Entrez Gene 100820829
UniGene
RefSeq NM_001018100 NM_152451
HUGO HGNC:43444
OMIM 614071
CCDS CCDS10162 CCDS42044
HPRD
IMGT
EMBL AC025271 AC090651
GenPept
RNA Seq Atlas 100820829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca