InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD3G

Summary

InnateDB Gene

IDBG-73647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD3G

Gene Name

CD3g molecule, gamma (CD3-TCR complex)

Synonyms

CD3-GAMMA; IMD17; T3G

Species

Homo sapiens

Ensembl Gene

ENSG00000160654

Encoded Proteins

IDBP-73649

CD3g molecule, gamma (CD3-TCR complex)

IDBP-244755

CD3g molecule, gamma (CD3-TCR complex)

IDBP-584276

CD3g molecule, gamma (CD3-TCR complex)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118344344-118355161

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000292144	ENSP00000292144
ENST00000392883	ENSP00000376621
ENST00000533462
ENST00000527777
ENST00000532917	ENSP00000431445
ENST00000528540
ENST00000532903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030159	receptor signaling complex scaffold activity
GO:0042608	T cell receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006461	protein complex assembly
GO:0007163	establishment or maintenance of cell polarity
GO:0007166	cell surface receptor signaling pathway
GO:0015031	protein transport
GO:0031295	T cell costimulation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110	T cell activation
GO:0045087	innate immune response
GO:0050776	regulation of immune response
GO:0050852	T cell receptor signaling pathway
GO:0070228	regulation of lymphocyte apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex