InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGAP22

Summary

InnateDB Gene

IDBG-73661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP22

Gene Name

Rho GTPase activating protein 22

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000128805

Encoded Proteins

IDBP-73663

Rho GTPase activating protein 22

IDBP-73665

Rho GTPase activating protein 22

IDBP-73667

Rho GTPase activating protein 22

IDBP-375057

Rho GTPase activating protein 22

IDBP-375059

Rho GTPase activating protein 22

IDBP-375061

Rho GTPase activating protein 22

IDBP-484981

Rho GTPase activating protein 22

IDBP-483372

Rho GTPase activating protein 22

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:48446034-48656265

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000374172	ENSP00000363287
ENST00000374170	ENSP00000363285
ENST00000249601	ENSP00000249601
ENST00000417912	ENSP00000412461
ENST00000417247	ENSP00000410054
ENST00000435790	ENSP00000416701
ENST00000477708	ENSP00000422868
ENST00000460425	ENSP00000422663
ENST00000515523
ENST00000471013
ENST00000489984
ENST00000493012
ENST00000491108
ENST00000511570
ENST00000464445

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0030154	cell differentiation
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000063506

View Gene Order

ENSBTAG00000007878

Not yet available

Pathways

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435063 Hs.629117 Hs.655672 Hs.690354

RefSeq

NM_001256024 NM_001256025 NM_001256026 NM_021226 XM_005270014 XM_006717934

HUGO

OMIM

CCDS

CCDS58079 CCDS58080 CCDS58081 CCDS7227

HPRD

12476

IMGT

EMBL

GenPept

RNA Seq Atlas