Version 5.4
Homo sapiens Gene: PDIA2
Summary
InnateDB Gene IDBG-7384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDIA2
Gene Name protein disulfide isomerase family A, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185615
Encoded Proteins
IDBP-7386
protein disulfide isomerase family A, member 2
IDBP-292514
protein disulfide isomerase family A, member 2
IDBP-361439
protein disulfide isomerase family A, member 2
IDBP-361442
protein disulfide isomerase family A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 [PubMed 8561901]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:283152-287215
Strand Forward strand
Band p13.3
Transcripts
ENST00000219406 ENSP00000219406
ENST00000404312 ENSP00000384410
ENST00000456379 ENSP00000392277
ENST00000435833 ENSP00000405081
ENST00000467212
ENST00000482665
ENST00000462950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0016853 isomerase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
Biological Process
GO:0006457 protein folding
GO:0006621 protein retention in ER lumen
GO:0008152 metabolic process
GO:0019511 peptidyl-proline hydroxylation
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024184
View Gene Order
ENSBTAG00000016575
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.66581
RefSeq NM_006849
HUGO
OMIM
CCDS CCDS42089
HPRD 07617
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca