InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GHRH

Summary

InnateDB Gene

IDBG-74024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHRH

Gene Name

growth hormone releasing hormone

Synonyms

GHRF; GRF; INN

Species

Homo sapiens

Ensembl Gene

ENSG00000118702

Encoded Proteins

IDBP-74026

growth hormone releasing hormone

IDBP-74028

growth hormone releasing hormone

IDBP-74030

growth hormone releasing hormone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:37251082-37261835

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000373614	ENSP00000362716
ENST00000373611	ENSP00000362713
ENST00000237527	ENSP00000237527

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0016608	growth hormone-releasing hormone activity
GO:0031770	growth hormone-releasing hormone receptor binding

Biological Process

GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0019933	cAMP-mediated signaling
GO:0021984	adenohypophysis development
GO:0030252	growth hormone secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032094	response to food
GO:0040018	positive regulation of multicellular organism growth
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep
GO:0046887	positive regulation of hormone secretion
GO:0060124	positive regulation of growth hormone secretion