InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EFNB1

Summary

InnateDB Gene

IDBG-74050.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNB1

Gene Name

ephrin-B1

Synonyms

CFND; CFNS; EFB1; EFL3; Elk-L; EPLG2; LERK2

Species

Homo sapiens

Ensembl Gene

ENSG00000090776

Encoded Proteins

IDBP-74052

ephrin-B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:68828997-68842147

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000204961

ENSP00000204961

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001755	neural crest cell migration
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0009880	embryonic pattern specification
GO:0042102	positive regulation of T cell proliferation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0045121	membrane raft
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome