Version 5.4
Homo sapiens Gene: SLC28A3
Summary
InnateDB Gene IDBG-74167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC28A3
Gene Name solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197506
Encoded Proteins
IDBP-74169
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:84275457-84340683
Strand Reverse strand
Band q21.33
Transcripts
ENST00000376238 ENSP00000365413
ENST00000495823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001882 nucleoside binding
GO:0005415 nucleoside:sodium symporter activity
GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity
GO:0015390 purine-specific nucleoside:sodium symporter activity
Biological Process
GO:0006810 transport
GO:0006863 purine nucleobase transport
GO:0015855 pyrimidine nucleobase transport
GO:0015860 purine nucleoside transmembrane transport
GO:0015864 pyrimidine nucleoside transport
GO:0055085 transmembrane transport
GO:0072531 pyrimidine-containing compound transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021553
View Gene Order
ENSBTAG00000018280
Not yet available
Pathways
NETPATH
REACTOME
REACT_1206
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9HAS3
TrEMBL
UniProt Splice Variant
Entrez Gene 64078
UniGene Hs.729999 Hs.730264
RefSeq NM_001199633 NM_022127
HUGO HGNC:16484
OMIM 608269
CCDS CCDS6670
HPRD
IMGT
EMBL AF305210 AK292849 AK304406 AK314039 AL353787 AL356134 BC093821 BC093823 CH471089
GenPept AAG22551 AAH93821 AAH93823 BAF85538 BAG36748 BAG65240 CAH73162 CAI16332 EAW62686
RNA Seq Atlas 64078

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca