Version 5.4
Homo sapiens Gene: WIPI2
Summary
InnateDB Gene IDBG-7422.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WIPI2
Gene Name WD repeat domain, phosphoinositide interacting 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157954
Encoded Proteins
IDBP-7424
WD repeat domain, phosphoinositide interacting 2
IDBP-7426
WD repeat domain, phosphoinositide interacting 2
IDBP-292606
WD repeat domain, phosphoinositide interacting 2
IDBP-292607
WD repeat domain, phosphoinositide interacting 2
IDBP-482108
WD repeat domain, phosphoinositide interacting 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5190188-5233826
Strand Forward strand
Band p22.1
Transcripts
ENST00000288828 ENSP00000288828
ENST00000382384 ENSP00000371821
ENST00000404704 ENSP00000385297
ENST00000401525 ENSP00000384945
ENST00000466014
ENST00000485854
ENST00000496867
ENST00000475309
ENST00000484262 ENSP00000429654
ENST00000465102
ENST00000480238
ENST00000488359
ENST00000471851
ENST00000479690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0000045 autophagic vacuole assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0034045 pre-autophagosomal structure membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029578
View Gene Order
ENSBTAG00000012049
Not yet available
Cross-References
SwissProt Q9Y4P8
TrEMBL A0A024R823
UniProt Splice Variant
Entrez Gene 26100
UniGene Hs.122363 Hs.700671
RefSeq NM_015610 XM_006715685 NM_001033518 NM_001033519 NM_001033520 NM_001278299 NM_016003
HUGO HGNC:32225
OMIM 609225
CCDS CCDS5339 CCDS34593 CCDS47531 CCDS47532 CCDS47533
HPRD 15679
IMGT
EMBL AC093376 AF151808 AK024279 AL080155 AY691425 AY691426 BC004116 BC007596 BC021068 BC021200 CH471144 CR533530
GenPept AAD34045 AAH04116 AAH07596 AAH21200 AAQ96865 AAQ96866 AAQ96867 AAV80761 AAV80762 BAG51284 CAB45746 CAG38561 EAW87326 EAW87327 EAW87328
RNA Seq Atlas 26100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca