Version 5.4
Homo sapiens Gene: NOSTRIN
Summary
InnateDB Gene IDBG-74325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOSTRIN
Gene Name nitric oxide synthase trafficker
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163072
Encoded Proteins
IDBP-74327
nitric oxide synthase trafficker
IDBP-235843
nitric oxide synthase trafficker
IDBP-235845
nitric oxide synthase trafficker
IDBP-387277
nitric oxide synthase trafficker
IDBP-387278
nitric oxide synthase trafficker
IDBP-387281
nitric oxide synthase trafficker
IDBP-387287
nitric oxide synthase trafficker
IDBP-387288
nitric oxide synthase trafficker
IDBP-387293
nitric oxide synthase trafficker
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:168786539-168865514
Strand Forward strand
Band q24.3
Transcripts
ENST00000317647 ENSP00000318921
ENST00000397209 ENSP00000380392
ENST00000397206 ENSP00000380390
ENST00000458381 ENSP00000402140
ENST00000439509 ENSP00000415337
ENST00000445023 ENSP00000404413
ENST00000444448 ENSP00000394051
ENST00000447264 ENSP00000390383
ENST00000427068 ENSP00000388597
ENST00000471833
ENST00000486873
ENST00000472260
ENST00000495202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046209 nitric oxide metabolic process
GO:0050999 regulation of nitric-oxide synthase activity
Cellular Component
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030666 endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034738
View Gene Order
ENSBTAG00000010362
Not yet available
Pathways
NETPATH
REACTOME
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8IVI9
TrEMBL E9PDM0 Q53TH8
UniProt Splice Variant
Entrez Gene 115677
UniGene Hs.189780
RefSeq NM_001171632 NM_001039724 NM_001171631 NM_052946
HUGO HGNC:20203
OMIM 607496
CCDS CCDS54416 CCDS42771 CCDS42772 CCDS54415
HPRD 06324
IMGT
EMBL AC009475 AC069137 AJ532842 AK002203 AK093444 AK290254 AL550371 BC014189 BC093072 DQ402497
GenPept AAH14189 AAH93072 AAX93055 AAY24097 ABD62889 BAE46614 BAF82943 BAG52717 CAD58724
RNA Seq Atlas 115677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca