Version 5.4
Homo sapiens Gene: BPI
Summary
InnateDB Gene IDBG-74654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BPI
Gene Name bactericidal/permeability-increasing protein
Synonyms BPIFD1; rBPI
Species Homo sapiens
Ensembl Gene ENSG00000101425
Encoded Proteins
IDBP-74656
bactericidal/permeability-increasing protein
IDBP-374880
bactericidal/permeability-increasing protein
IDBP-374883
bactericidal/permeability-increasing protein
IDBP-374899
bactericidal/permeability-increasing protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:38260149-38337505
Strand Forward strand
Band q11.23
Transcripts
ENST00000262865 ENSP00000262865
ENST00000418004 ENSP00000393126
ENST00000451435 ENSP00000391511
ENST00000417318 ENSP00000409833
ENST00000479646
ENST00000489102
ENST00000489039
ENST00000490381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0008289 lipid binding
Biological Process
GO:0006955 immune response
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0042742 defense response to bacterium
GO:0043031 negative regulation of macrophage activation
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000052922
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529019 Hs.628250 Hs.635948
RefSeq NM_001725 XM_005260523
HUGO
OMIM
CCDS CCDS13303
HPRD 00174
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca