Version 5.4
| Homo sapiens Gene: TECTA | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-74695.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TECTA | ||||||||
| Gene Name | tectorin alpha | ||||||||
| Synonyms | DFNA12; DFNA8; DFNB21 | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000109927 | ||||||||
| Encoded Proteins |
tectorin alpha
tectorin alpha
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008] The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 11:121101173-121191493 | ||||||||
| Strand | Forward strand | ||||||||
| Band | q23.3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||
| SwissProt | O75443 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 7007 | ||||||||
| UniGene | Hs.248162 Hs.731790 | ||||||||
| RefSeq | NM_005422 XM_005271653 | ||||||||
| HUGO | HGNC:11720 | ||||||||
| OMIM | 602574 | ||||||||
| CCDS | CCDS8434 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF055114 AF055115 AF055116 AF055117 AF055118 AF055119 AF055120 AF055121 AF055122 AF055123 AF055124 AF055125 AF055126 AF055127 AF055128 AF055129 AF055130 AF055131 AF055132 AF055133 AF055134 AF055135 AF055136 AP000646 AP000826 | ||||||||
| GenPept | AAC26019 | ||||||||
| RNA Seq Atlas | 7007 | ||||||||