Homo sapiens Gene: UBASH3B
Summary
InnateDB Gene IDBG-74798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBASH3B
Gene Name ubiquitin associated and SH3 domain containing B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154127
Encoded Proteins
ubiquitin associated and SH3 domain containing B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:122655675-122814473
Strand Forward strand
Band q24.1
Transcripts
ENST00000284273 ENSP00000284273
ENST00000525711
ENST00000526386
ENST00000530917
ENST00000533451
ENST00000529998
ENST00000526493
ENST00000530578
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
Experimentally validated
Total 85 [view]
Protein-Protein 85 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0090331 negative regulation of platelet aggregation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444075
RefSeq NM_032873 XM_005271712
HUGO
OMIM
CCDS CCDS31694
HPRD 16463
IMGT
EMBL
GenPept
RNA Seq Atlas