InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2D1

Summary

InnateDB Gene

IDBG-74933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2D1

Gene Name

ubiquitin-conjugating enzyme E2D 1

Synonyms

E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A

Species

Homo sapiens

Ensembl Gene

ENSG00000072401

Encoded Proteins

IDBP-74937

ubiquitin-conjugating enzyme E2D 1

IDBP-807758

ubiquitin-conjugating enzyme E2D 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:58334975-58370753

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000373910	ENSP00000363019
ENST00000473824
ENST00000606483
ENST00000615793	ENSP00000479814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 299 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	299 [view]
Protein-Protein	297 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007094	mitotic spindle assembly checkpoint
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0030509	BMP signaling pathway
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0045087	innate immune response
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070936	protein K48-linked ubiquitination
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019927

View Gene Order

ENSBTAG00000020796

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_1072

Inactivation of APC/C via direct inhibition of the APC/C complex pathway

REACT_1041

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway

REACT_6761

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway

REACT_6820

APC/C:Cdc20 mediated degradation of Cyclin B pathway

REACT_6871

APC/C:Cdc20 mediated degradation of Securin pathway

REACT_6781

APC/C:Cdc20 mediated degradation of mitotic proteins pathway

REACT_6904

Phosphorylation of the APC/C pathway

REACT_6785

Autodegradation of Cdh1 by Cdh1:APC/C pathway

REACT_6867

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway

REACT_6837

Regulation of APC/C activators between G1/S and early anaphase pathway

REACT_150471

Separation of Sister Chromatids pathway

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_25271

Negative regulators of RIG-I/MDA5 signaling pathway

REACT_25359

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

REACT_25374

IKK complex recruitment mediated by RIP1 pathway

REACT_6809

MyD88-independent cascade pathway

REACT_6783

Toll Like Receptor 3 (TLR3) Cascade pathway

REACT_6894

Toll Like Receptor 4 (TLR4) Cascade pathway

REACT_121111

Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway

REACT_12034

Signaling by BMP pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_120916

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway

REACT_120956

Cellular responses to stress pathway

REACT_169107

SMAD4 MH2 Domain Mutants in Cancer pathway

REACT_6828

APC/C-mediated degradation of cell cycle proteins pathway

REACT_169219

Loss of Function of SMAD4 in Cancer pathway

REACT_169398

Loss of Function of SMAD2/3 in Cancer pathway

REACT_6954

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway

REACT_21279

Regulation of mitotic cell cycle pathway

REACT_169122

Signaling by TGF-beta Receptor Complex in Cancer pathway

REACT_6802

Innate Immune System pathway

REACT_6966

Toll-Like Receptors Cascades pathway

REACT_169192

TGFBR2 MSI Frameshift Mutants in Cancer pathway

REACT_111102

Signal Transduction pathway

REACT_121061

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway

REACT_169165

SMAD2/3 MH2 Domain Mutants in Cancer pathway

REACT_169435

Loss of Function of TGFBR2 in Cancer pathway

REACT_115566

Cell Cycle pathway

REACT_75774

Adaptive Immune System pathway

REACT_120815

Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway

REACT_2137

Mitotic Spindle Checkpoint pathway

REACT_6900

Immune System pathway

REACT_169103

SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway

REACT_121311

Cellular response to hypoxia pathway

REACT_910

M Phase pathway

REACT_169274

Cellular Senescence pathway

REACT_1275

Mitotic Anaphase pathway

REACT_169263

TGFBR1 KD Mutants in Cancer pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_6890

Activated TLR4 signalling pathway

REACT_169311

Loss of Function of TGFBR1 in Cancer pathway

REACT_169445

TGFBR1 LBD Mutants in Cancer pathway

REACT_169168

Senescence-Associated Secretory Phenotype (SASP) pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

REACT_169440

TGFBR2 Kinase Domain Mutants in Cancer pathway

REACT_25281

TRIF-mediated TLR3/TLR4 signaling pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_6844

Signaling by TGF-beta Receptor Complex pathway

REACT_1538

Cell Cycle Checkpoints pathway

REACT_150314

Mitotic Metaphase and Anaphase pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

p53regulationpathway

p53 pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

7321

UniGene

RefSeq

NM_001204880 NM_003338

HUGO

HGNC:12474

OMIM

602961

CCDS

CCDS73139 CCDS7252

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

7321