Version 5.4
Homo sapiens Gene: TFAM
Summary
InnateDB Gene IDBG-74965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFAM
Gene Name transcription factor A, mitochondrial
Synonyms MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3
Species Homo sapiens
Ensembl Gene ENSG00000108064
Encoded Proteins
IDBP-74969
transcription factor A, mitochondrial
IDBP-239691
transcription factor A, mitochondrial
IDBP-480746
transcription factor A, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer\'s and Parkinson\'s diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:58385022-58399221
Strand Forward strand
Band q21.1
Transcripts
ENST00000373899
ENST00000373895 ENSP00000363002
ENST00000395377 ENSP00000378776
ENST00000487519 ENSP00000420588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0031072 heat shock protein binding
GO:0044822 poly(A) RNA binding
GO:0070363 mitochondrial light strand promoter sense binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006390 transcription from mitochondrial promoter
GO:0006391 transcription initiation from mitochondrial promoter
GO:0010467 gene expression
GO:0033108 mitochondrial respiratory chain complex assembly
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003923
View Gene Order
ENSBTAG00000003546
Not yet available
Pathways
NETPATH
REACTOME
REACT_367
Mitochondrial transcription initiation pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_1484
Transcription from mitochondrial promoters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt Q00059
TrEMBL E5KSU5
UniProt Splice Variant
Entrez Gene 7019
UniGene
RefSeq NM_001270782 NM_003201
HUGO HGNC:11741
OMIM 600438
CCDS CCDS59217 CCDS7253
HPRD
IMGT
EMBL AB451241 AB451366 AC023170 AK312558 BC126366 BT019658 BT019659 CH471083 EU279428 HQ206066 HQ206067 HQ206068 HQ206069 HQ206070 HQ206071 HQ206072 HQ206073 HQ206074 HQ206075 HQ206076 HQ206077 HQ206078 HQ206079 HQ206080 HQ206081 HQ206082 HQ206083 HQ206084 HQ206085 HQ206086 HQ206087 HQ206088 HQ206089 HQ206090 HQ206091 HQ206092 HQ206093 HQ206094 HQ206095 HQ206096 HQ206097 HQ206098 HQ206100 HQ206101 HQ206102 HQ206103 HQ206104 HQ206105 M62810 X64269
GenPept AAA59849 AAI26367 AAV38464 AAV38465 ABX72056 ADP91974 ADP91975 ADP91976 ADP91977 ADP91978 ADP91979 ADP91980 ADP91981 ADP91982 ADP91983 ADP91984 ADP91985 ADP91986 ADP91987 ADP91988 ADP91989 ADP91990 ADP91991 ADP91992 ADP91993 ADP91994 ADP91995 ADP91996 ADP91997 ADP91998 ADP91999 ADP92000 ADP92001 ADP92002 ADP92003 ADP92004 ADP92005 ADP92006 ADP92008 ADP92009 ADP92010 ADP92011 ADP92012 ADP92013 BAG35455 BAG70055 BAG70180 CAA45562 EAW54173 EAW54175
RNA Seq Atlas 7019

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca