InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTSL1

Summary

InnateDB Gene

IDBG-74981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSL1

Gene Name

cathepsin L1

Synonyms

CATL; CTSL1; MEP

Species

Homo sapiens

Ensembl Gene

ENSG00000135047

Encoded Proteins

IDBP-74985

cathepsin L1

IDBP-74987

cathepsin L1

IDBP-77613

cathepsin L1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20926012

CTSL1 enhances angiogenesis by increasing extracellular matrix degradation and remodelling.

PMID 24315997

T cell-expressed CTSL1 cleaves C3 into active C3a and C3b fragments mediating the intracellular and extracellular C3 activation in T cells.

Entrez Gene

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:87725519-87731393

Strand

Forward strand

Band

q21.33

Transcripts

ENST00000340342	ENSP00000365061
ENST00000342020	ENSP00000340470
ENST00000375894
ENST00000343150	ENSP00000345344
ENST00000495822
ENST00000482054

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008234	cysteine-type peptidase activity
GO:0042393	histone binding
GO:0043394	proteoglycan binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002250	adaptive immune response
GO:0006508	proteolysis
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071888	macrophage apoptotic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005764	lysosome
GO:0036021	endolysosome lumen
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome