Version 5.4
Homo sapiens Gene: PDK1
Summary
InnateDB Gene IDBG-75174.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDK1
Gene Name pyruvate dehydrogenase kinase, isozyme 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152256
Encoded Proteins
IDBP-75176
pyruvate dehydrogenase kinase, isozyme 1
IDBP-245392
pyruvate dehydrogenase kinase, isozyme 1
IDBP-293612
pyruvate dehydrogenase kinase, isozyme 1
IDBP-387582
pyruvate dehydrogenase kinase, isozyme 1
IDBP-387583
pyruvate dehydrogenase kinase, isozyme 1
IDBP-387586
pyruvate dehydrogenase kinase, isozyme 1
IDBP-387587
pyruvate dehydrogenase kinase, isozyme 1
IDBP-387588
pyruvate dehydrogenase kinase, isozyme 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq, Jul 2008]
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:172555373-172608669
Strand Forward strand
Band q31.1
Transcripts
ENST00000282077 ENSP00000282077
ENST00000392571 ENSP00000376352
ENST00000410055 ENSP00000386985
ENST00000443353 ENSP00000399558
ENST00000436490 ENSP00000406608
ENST00000431718 ENSP00000413629
ENST00000416991 ENSP00000399160
ENST00000439519 ENSP00000388366
ENST00000466437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006006 glucose metabolic process
GO:0006090 pyruvate metabolic process
GO:0006468 protein phosphorylation
GO:0008283 cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906 regulation of glucose metabolic process
GO:0016310 phosphorylation
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0097411 hypoxia-inducible factor-1alpha signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005967 mitochondrial pyruvate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006494
View Gene Order
ENSBTAG00000016836
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_12528
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_2071
Pyruvate metabolism pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470633
RefSeq NM_001278549 NM_002610 XM_006712595
HUGO
OMIM
CCDS CCDS2250 CCDS63059
HPRD 03954
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca