Version 5.4
Homo sapiens Gene: ANK3
Summary
InnateDB Gene IDBG-75198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANK3
Gene Name ankyrin 3, node of Ranvier (ankyrin G)
Synonyms ANKYRIN-G; MRT37
Species Homo sapiens
Ensembl Gene ENSG00000151150
Encoded Proteins
IDBP-75200
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-75202
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-75204
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-75206
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-75210
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-477050
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-483201
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-474538
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-481053
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809776
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-485479
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-474270
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-478065
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809792
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-485478
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-484386
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-476849
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809769
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809771
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809772
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809773
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809774
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809775
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809779
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809787
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809791
ankyrin 3, node of Ranvier (ankyrin G)
IDBP-809800
ankyrin 3, node of Ranvier (ankyrin G)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:60026298-60733490
Strand Reverse strand
Band q21.2
Transcripts
ENST00000280772 ENSP00000280772
ENST00000373827 ENSP00000362933
ENST00000355288 ENSP00000347436
ENST00000373820 ENSP00000362926
ENST00000373815 ENSP00000362921
ENST00000502769 ENSP00000423057
ENST00000489505
ENST00000480699
ENST00000503366 ENSP00000425236
ENST00000469721
ENST00000514197 ENSP00000427121
ENST00000511043 ENSP00000426258
ENST00000459732 ENSP00000480249
ENST00000508449
ENST00000465749
ENST00000467420 ENSP00000423968
ENST00000513049 ENSP00000426582
ENST00000506635 ENSP00000422506
ENST00000486349 ENSP00000483483
ENST00000460468 ENSP00000426690
ENST00000474360 ENSP00000422657
ENST00000503925 ENSP00000426011
ENST00000510382
ENST00000612776 ENSP00000481611
ENST00000617800 ENSP00000480745
ENST00000616444 ENSP00000482401
ENST00000610321 ENSP00000477827
ENST00000610901 ENSP00000479337
ENST00000613207 ENSP00000477814
ENST00000621739 ENSP00000478037
ENST00000622427 ENSP00000483244
ENST00000618080 ENSP00000482307
ENST00000618374 ENSP00000479018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0030507 spectrin binding
GO:0030674 protein binding, bridging
GO:0044325 ion channel binding
GO:0045296 cadherin binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0007009 plasma membrane organization
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0010628 positive regulation of gene expression
GO:0010650 positive regulation of cell communication by electrical coupling
GO:0010765 positive regulation of sodium ion transport
GO:0019228 neuronal action potential
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0043001 Golgi to plasma membrane protein transport
GO:0043266 regulation of potassium ion transport
GO:0045184 establishment of protein localization
GO:0045838 positive regulation of membrane potential
GO:0050808 synapse organization
GO:0071709 membrane assembly
GO:0072659 protein localization to plasma membrane
GO:0072660 maintenance of protein location in plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:1900827 positive regulation of membrane depolarization during cardiac muscle cell action potential
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0014704 intercalated disc
GO:0014731 spectrin-associated cytoskeleton
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030424 axon
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0033268 node of Ranvier
GO:0033270 paranode region of axon
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043034 costamere
GO:0043194 axon initial segment
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069601
View Gene Order
ENSBTAG00000019052
Not yet available
Pathways
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001149 NM_001204403 NM_001204404 NM_020987 XM_005269715 XM_005269716 XM_006717786 XM_006717788 XM_006717789 XM_006717798
HUGO
OMIM
CCDS CCDS55711 CCDS55712 CCDS7258 CCDS7259
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca