Version 5.4
Homo sapiens Gene: NRGN
Summary
InnateDB Gene IDBG-75248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRGN
Gene Name neurogranin (protein kinase C substrate, RC3)
Synonyms hng; RC3
Species Homo sapiens
Ensembl Gene ENSG00000154146
Encoded Proteins
IDBP-75250
neurogranin (protein kinase C substrate, RC3)
IDBP-384319
neurogranin (protein kinase C substrate, RC3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:124739846-124747210
Strand Forward strand
Band q24.2
Transcripts
ENST00000284292 ENSP00000284292
ENST00000412681 ENSP00000399591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007165 signal transduction
GO:0007399 nervous system development
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053310
View Gene Order
ENSBTAG00000001474
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.722314
RefSeq NM_001126181 NM_006176
HUGO
OMIM
CCDS CCDS8451
HPRD 03828
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca