Version 5.4
Homo sapiens Gene: CDK1
Summary
InnateDB Gene IDBG-75344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK1
Gene Name cyclin-dependent kinase 1
Synonyms CDC2; CDC28A; P34CDC2
Species Homo sapiens
Ensembl Gene ENSG00000170312
Encoded Proteins
IDBP-75350
cyclin-dependent kinase 1
IDBP-75352
cyclin-dependent kinase 1
IDBP-239863
cyclin-dependent kinase 1
IDBP-377289
cyclin-dependent kinase 1
IDBP-478005
cyclin-dependent kinase 1
IDBP-806901
cyclin-dependent kinase 1
IDBP-806903
cyclin-dependent kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:60778331-60794852
Strand Forward strand
Band q21.2
Transcripts
ENST00000316629 ENSP00000325970
ENST00000373809 ENSP00000362915
ENST00000395284 ENSP00000378699
ENST00000448257 ENSP00000397973
ENST00000519078 ENSP00000430665
ENST00000475504
ENST00000519760
ENST00000487784
ENST00000614696 ENSP00000482996
ENST00000613147 ENSP00000481503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 242 [view]
Protein-Protein 236 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
GO:0030544 Hsp70 protein binding
GO:0035173 histone kinase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006461 protein complex assembly
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007098 centrosome cycle
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007344 pronuclear fusion
GO:0007411 axon guidance
GO:0007569 cell aging
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009636 response to toxic substance
GO:0010243 response to organonitrogen compound
GO:0010628 positive regulation of gene expression
GO:0014038 regulation of Schwann cell differentiation
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0014823 response to activity
GO:0016477 cell migration
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030261 chromosome condensation
GO:0030855 epithelial cell differentiation
GO:0031100 organ regeneration
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0034501 protein localization to kinetochore
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045740 positive regulation of DNA replication
GO:0045931 positive regulation of mitotic cell cycle
GO:0045995 regulation of embryonic development
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048678 response to axon injury
GO:0051403 stress-activated MAPK cascade
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0055015 ventricular cardiac muscle cell development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0070301 cellular response to hydrogen peroxide
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0016020 membrane
GO:0030496 midbody
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019942
View Gene Order
ENSBTAG00000010109
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_1846
G2/M DNA replication checkpoint pathway
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6904
Phosphorylation of the APC/C pathway
REACT_6875
Phosphorylation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1100
Golgi Cisternae Pericentriolar Stack Reorganization pathway
REACT_160122
Activation of NIMA Kinases NEK9, NEK6, NEK7 pathway
REACT_150182
MASTL Facilitates Mitotic Progression pathway
REACT_150260
Condensation of Prometaphase Chromosomes pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_6362
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_2101
Cyclin B2 mediated events pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15510
Recruitment of NuMA to mitotic centrosomes pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_1391
ERK1 activation pathway
REACT_1482
ERK activation pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_524
SOS-mediated signalling pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_661
SHC-mediated signalling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_12529
Signaling by VEGF pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_828
G2/M Checkpoints pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_634
RAF/MAP kinase cascade pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_1783
G1/S Transition pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_332
IRS-mediated signalling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_910
M Phase pathway
REACT_15479
Centrosome maturation pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_2203
G2/M Transition pathway
REACT_762
IRS-related events pathway
REACT_765
Mitotic Prophase pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_200828
Depolymerisation of the Nuclear Lamina pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04540
Gap junction pathway
hsa04110
Cell cycle pathway
hsa04115
p53 signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
ap1_pathway
AP-1 transcription factor network
e2f_pathway
E2F transcription factor network
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
foxm1pathway
FOXM1 transcription factor network
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623223 Hs.732435
RefSeq NM_001786 NM_033379 XM_005270303 XM_006718082 XM_006718083
HUGO
OMIM
CCDS CCDS44408 CCDS7260
HPRD 00302
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca