Version 5.4
Homo sapiens Gene: PTPRT
Summary
InnateDB Gene IDBG-75554.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRT
Gene Name protein tyrosine phosphatase, receptor type, T
Synonyms RPTPrho
Species Homo sapiens
Ensembl Gene ENSG00000196090
Encoded Proteins
IDBP-75556
protein tyrosine phosphatase, receptor type, T
IDBP-75558
protein tyrosine phosphatase, receptor type, T
IDBP-75560
protein tyrosine phosphatase, receptor type, T
IDBP-75562
protein tyrosine phosphatase, receptor type, T
IDBP-75564
protein tyrosine phosphatase, receptor type, T
IDBP-75566
protein tyrosine phosphatase, receptor type, T
IDBP-75568
protein tyrosine phosphatase, receptor type, T
IDBP-813462
protein tyrosine phosphatase, receptor type, T
IDBP-813464
protein tyrosine phosphatase, receptor type, T
IDBP-813465
protein tyrosine phosphatase, receptor type, T
IDBP-813467
protein tyrosine phosphatase, receptor type, T
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:42072752-43189970
Strand Reverse strand
Band q13.11
Transcripts
ENST00000373201 ENSP00000362297
ENST00000373198 ENSP00000362294
ENST00000373193 ENSP00000362289
ENST00000373190 ENSP00000362286
ENST00000373184 ENSP00000362280
ENST00000356100 ENSP00000348408
ENST00000373187 ENSP00000362283
ENST00000485499
ENST00000617474 ENSP00000484248
ENST00000618610 ENSP00000484524
ENST00000620410 ENSP00000480136
ENST00000612229 ENSP00000481466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016790 thiolester hydrolase activity
GO:0016791 phosphatase activity
GO:0045294 alpha-catenin binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0051393 alpha-actinin binding
GO:0070097 delta-catenin binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053141
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.526879
RefSeq NM_007050 NM_133170 XM_006723689
HUGO
OMIM
CCDS CCDS42874 CCDS68127
HPRD 06690
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca