InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX17

Summary

InnateDB Gene

IDBG-7557.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX17

Gene Name

DEAD (Asp-Glu-Ala-Asp) box helicase 17

Synonyms

P72; RH70

Species

Homo sapiens

Ensembl Gene

ENSG00000100201

Encoded Proteins

IDBP-236690

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

IDBP-293576

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:38483440-38507660

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000216019
ENST00000396821	ENSP00000380033
ENST00000403230	ENSP00000385536
ENST00000431312
ENST00000432525
ENST00000475004
ENST00000497196
ENST00000477112
ENST00000467279
ENST00000479734

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	166 [view]
Protein-Protein	151 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	11 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008186	RNA-dependent ATPase activity
GO:0030331	estrogen receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006396	RNA processing
GO:0009791	post-embryonic development
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072358	cardiovascular system development
GO:2001014	regulation of skeletal muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055065

View Gene Order

ENSBTAG00000009887

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

Cross-References

SwissProt

Q92841

TrEMBL

G5E9L5 H3BLZ8 Q9UQL5

UniProt Splice Variant

Entrez Gene

10521

UniGene

Hs.614336 Hs.618122 Hs.705517 Hs.733015 Hs.741903 Hs.743309 Hs.743341

RefSeq

NM_001098504 NM_006386

HUGO

HGNC:2740

OMIM

608469

CCDS

CCDS33646 CCDS46706

HPRD

IMGT

EMBL

AF131750 AL713763 BC000595 CH471095 CR456432 U59321 Z97056

GenPept

AAC50787 AAD20033 AAH00595 CAB09792 CAG30318 CAH10627 CAQ08924 EAW60241 EAW60243

RNA Seq Atlas

10521