Version 5.4
Homo sapiens Gene: CHN1
Summary
InnateDB Gene IDBG-75593.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHN1
Gene Name chimerin 1
Synonyms ARHGAP2; CHN; DURS2; NC; RHOGAP2
Species Homo sapiens
Ensembl Gene ENSG00000128656
Encoded Proteins
IDBP-75595
chimerin (chimaerin) 1
IDBP-293554
chimerin (chimaerin) 1
IDBP-293556
chimerin (chimaerin) 1
IDBP-293547
chimerin (chimaerin) 1
IDBP-293548
chimerin (chimaerin) 1
IDBP-387704
chimerin (chimaerin) 1
IDBP-387705
chimerin (chimaerin) 1
IDBP-387707
chimerin (chimaerin) 1
IDBP-387708
chimerin (chimaerin) 1
IDBP-387709
chimerin (chimaerin) 1
IDBP-387710
chimerin (chimaerin) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane\'s retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:174799363-175005369
Strand Reverse strand
Band q31.1
Transcripts
ENST00000295497 ENSP00000295497
ENST00000409900 ENSP00000386741
ENST00000409156 ENSP00000386470
ENST00000409089 ENSP00000386322
ENST00000409597 ENSP00000386469
ENST00000444394 ENSP00000411911
ENST00000413882 ENSP00000410496
ENST00000443238 ENSP00000409798
ENST00000425395 ENSP00000405270
ENST00000444573 ENSP00000392603
ENST00000451799 ENSP00000416316
ENST00000488080
ENST00000492964
ENST00000491801
ENST00000485882
ENST00000481174
ENST00000490654
ENST00000469597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008045 motor neuron axon guidance
GO:0009967 positive regulation of signal transduction
GO:0032314 regulation of Rac GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056486
View Gene Order
ENSBTAG00000008028
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.380138 Hs.724104
RefSeq NM_001025201 NM_001206602 NM_001822
HUGO
OMIM
CCDS CCDS46454 CCDS46455 CCDS56147
HPRD 00319
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca