Version 5.4
Homo sapiens Gene: L3MBTL1
Summary
InnateDB Gene IDBG-75814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol L3MBTL1
Gene Name l(3)mbt-like 1 (Drosophila)
Synonyms dJ138B7.3; H-L(3)MBT; L3MBTL; ZC2HC3
Species Homo sapiens
Ensembl Gene ENSG00000185513
Encoded Proteins
IDBP-75818
l(3)mbt-like 1 (Drosophila)
IDBP-75820
l(3)mbt-like 1 (Drosophila)
IDBP-375533
l(3)mbt-like 1 (Drosophila)
IDBP-375570
l(3)mbt-like 1 (Drosophila)
IDBP-375571
l(3)mbt-like 1 (Drosophila)
IDBP-375575
l(3)mbt-like 1 (Drosophila)
IDBP-375616
l(3)mbt-like 1 (Drosophila)
IDBP-375620
l(3)mbt-like 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:43507680-43550950
Strand Forward strand
Band q13.12
Transcripts
ENST00000373135 ENSP00000362227
ENST00000373134 ENSP00000362226
ENST00000373133
ENST00000434666 ENSP00000415971
ENST00000418998 ENSP00000398516
ENST00000439769 ENSP00000387971
ENST00000427442 ENSP00000402107
ENST00000430781
ENST00000457824
ENST00000422861 ENSP00000410139
ENST00000445228 ENSP00000412938
ENST00000473289
ENST00000468336
ENST00000473981
ENST00000485334
ENST00000497347
ENST00000483547
ENST00000494117
ENST00000471977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 32 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031491 nucleosome binding
GO:0031493 nucleosomal histone binding
GO:0032093 SAM domain binding
GO:0035064 methylated histone binding
GO:0042393 histone binding
GO:0042802 identical protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007088 regulation of mitosis
GO:0016568 chromatin modification
GO:0030097 hemopoiesis
GO:0045652 regulation of megakaryocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000785 chromatin
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000035576
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 26013
UniGene Hs.609201 Hs.709356
RefSeq NM_015478 NM_032107
HUGO HGNC:15905
OMIM 608802
CCDS CCDS13319 CCDS46602
HPRD 16387
IMGT
EMBL
GenPept
RNA Seq Atlas 26013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca