InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SIRT1

Summary

InnateDB Gene

IDBG-75847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT1

Gene Name

sirtuin 1

Synonyms

SIR2L1

Species

Homo sapiens

Ensembl Gene

ENSG00000096717

Encoded Proteins

IDBP-75849

sirtuin 1

IDBP-292931

sirtuin 1

IDBP-292930

sirtuin 1

IDBP-377635

sirtuin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21245135

SIRT1 is a histone deacetylase enzyme that has been found to accumulate at the promoters of TNFA and IL1B in response to TLR4 signalling. SIRT1 promotes termination of NFKB-dependent transcription and recruits RELB to assemble transcription repressor complex that generates endotoxin tolerance.

InnateDB Annotation from Orthologs

Summary

PMID 21245135

[Mus musculus] Sirt1 is a histone deacetylase enzyme that has been found to accumulate at the promoters of Tnfa and Il1b in response to Tlr4 signalling. Sirt1 promotes termination of NFKB-dependent transcription and recruits Relb to assemble transcription repressor complex that generates endotoxin tolerance.

Entrez Gene

Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:67884669-67918390

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000212015	ENSP00000212015
ENST00000406900	ENSP00000384508
ENST00000403579	ENSP00000384063
ENST00000432464	ENSP00000409208
ENST00000497639
ENST00000473922

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 383 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	383 [view]
Protein-Protein	268 [view]
Protein-DNA	6 [view]
Protein-RNA	1 [view]
DNA-DNA	108 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0017136	NAD-dependent histone deacetylase activity
GO:0019213	deacetylase activity
GO:0019899	enzyme binding
GO:0033558	protein deacetylase activity
GO:0034979	NAD-dependent protein deacetylase activity
GO:0042393	histone binding
GO:0042802	identical protein binding
GO:0043398	HLH domain binding
GO:0043425	bHLH transcription factor binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0051019	mitogen-activated protein kinase binding
GO:0070403	NAD+ binding
GO:1990254	keratin filament binding

Biological Process

GO:0000012	single strand break repair
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000183	chromatin silencing at rDNA
GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0000731	DNA synthesis involved in DNA repair
GO:0001525	angiogenesis
GO:0001542	ovulation from ovarian follicle
GO:0001678	cellular glucose homeostasis
GO:0001934	positive regulation of protein phosphorylation
GO:0002821	positive regulation of adaptive immune response
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006325	chromatin organization
GO:0006342	chromatin silencing
GO:0006343	establishment of chromatin silencing
GO:0006344	maintenance of chromatin silencing
GO:0006346	methylation-dependent chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0006476	protein deacetylation
GO:0006642	triglyceride mobilization
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007283	spermatogenesis
GO:0007346	regulation of mitotic cell cycle
GO:0007517	muscle organ development
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0009267	cellular response to starvation
GO:0010875	positive regulation of cholesterol efflux
GO:0010906	regulation of glucose metabolic process
GO:0016032	viral process
GO:0016239	positive regulation of macroautophagy
GO:0016567	protein ubiquitination
GO:0016575	histone deacetylation
GO:0018394	peptidyl-lysine acetylation
GO:0030308	negative regulation of cell growth
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031393	negative regulation of prostaglandin biosynthetic process
GO:0031648	protein destabilization
GO:0031667	response to nutrient levels
GO:0031937	positive regulation of chromatin silencing
GO:0032007	negative regulation of TOR signaling
GO:0032071	regulation of endodeoxyribonuclease activity
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032868	response to insulin
GO:0033158	regulation of protein import into nucleus, translocation
GO:0034391	regulation of smooth muscle cell apoptotic process
GO:0034983	peptidyl-lysine deacetylation
GO:0035356	cellular triglyceride homeostasis
GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042326	negative regulation of phosphorylation
GO:0042542	response to hydrogen peroxide
GO:0042632	cholesterol homeostasis
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response (InnateDB)
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045599	negative regulation of fat cell differentiation
GO:0045739	positive regulation of DNA repair
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050872	white fat cell differentiation
GO:0051097	negative regulation of helicase activity
GO:0051574	positive regulation of histone H3-K9 methylation
GO:0051898	negative regulation of protein kinase B signaling
GO:0055089	fatty acid homeostasis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0070301	cellular response to hydrogen peroxide
GO:0070857	regulation of bile acid biosynthetic process
GO:0070932	histone H3 deacetylation
GO:0071356	cellular response to tumor necrosis factor
GO:0071456	cellular response to hypoxia
GO:0071479	cellular response to ionizing radiation
GO:1901215	negative regulation of neuron death
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000111	positive regulation of macrophage apoptotic process
GO:2000480	negative regulation of cAMP-dependent protein kinase activity
GO:2000481	positive regulation of cAMP-dependent protein kinase activity
GO:2000655	negative regulation of cellular response to testosterone stimulus
GO:2000757	negative regulation of peptidyl-lysine acetylation
GO:2000773	negative regulation of cellular senescence
GO:2000774	positive regulation of cellular senescence

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005654	nucleoplasm
GO:0005677	chromatin silencing complex
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016605	PML body
GO:0033553	rDNA heterochromatin
GO:0035098	ESC/E(Z) complex