Version 5.4
Homo sapiens Gene: AGPS
Summary
InnateDB Gene IDBG-75882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGPS
Gene Name alkylglycerone phosphate synthase
Synonyms ADAP-S; ADAS; ADHAPS; ADPS; ALDHPSY
Species Homo sapiens
Ensembl Gene ENSG00000018510
Encoded Proteins
IDBP-75884
alkylglycerone phosphate synthase
IDBP-293494
alkylglycerone phosphate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:177392644-177543836
Strand Forward strand
Band q31.2
Transcripts
ENST00000264167 ENSP00000264167
ENST00000409888 ENSP00000386688
ENST00000460342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 19 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008609 alkylglycerone-phosphate synthase activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0008610 lipid biosynthetic process
GO:0008611 ether lipid biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042410
View Gene Order
ENSBTAG00000009897
Not yet available
Pathways
NETPATH
REACTOME
REACT_1407
Plasmalogen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00565
Ether lipid metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B8ZZ81
UniProt Splice Variant
Entrez Gene 8540
UniGene Hs.516543 Hs.604884
RefSeq NM_003659
HUGO HGNC:327
OMIM 603051
CCDS CCDS2275
HPRD 04337
IMGT
EMBL AC016762 AC019080 AC073834
GenPept
RNA Seq Atlas 8540

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca