Version 5.4
Homo sapiens Gene: ACTB
Summary
InnateDB Gene IDBG-7590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTB
Gene Name actin, beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000075624
Encoded Proteins
IDBP-7592
actin, beta
IDBP-362970
actin, beta
IDBP-362978
actin, beta
IDBP-362983
actin, beta
IDBP-362989
actin, beta
IDBP-362990
actin, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:5527151-5563784
Strand Reverse strand
Band p22.1
Transcripts
ENST00000331789 ENSP00000349960
ENST00000425660 ENSP00000409264
ENST00000432588 ENSP00000407473
ENST00000443528 ENSP00000393951
ENST00000417101 ENSP00000399487
ENST00000414620 ENSP00000401032
ENST00000464611
ENST00000462494
ENST00000493945
ENST00000484841
ENST00000473257
ENST00000477812
ENST00000480301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 302 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 302 [view]
Protein-Protein 296 [view]
Protein-DNA 4 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0030957 Tat protein binding
GO:0031492 nucleosomal DNA binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0001895 retina homeostasis
GO:0006325 chromatin organization
GO:0006457 protein folding
GO:0006928 cellular component movement
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0021762 substantia nigra development
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043044 ATP-dependent chromatin remodeling
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response
GO:0045216 cell-cell junction organization
GO:0051084 'de novo' posttranslational protein folding
GO:0061024 membrane organization
Cellular Component
GO:0000790 nuclear chromatin
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0030529 ribonucleoprotein complex
GO:0030863 cortical cytoskeleton
GO:0035267 NuA4 histone acetyltransferase complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0070688 MLL5-L complex
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000029580
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_17050
Folding of actin by CCT/TriC pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_19195
Adherens junctions interactions pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_172610
HATs acetylate histones pathway
REACT_16952
Protein folding pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_172623
Chromatin organization pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_19331
Cell-cell junction organization pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05110
Vibrio cholerae infection pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05416
Viral myocarditis pathway
hsa04971
Gastric acid secretion pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596179 Hs.600606 Hs.601060 Hs.675971 Hs.692692 Hs.731069
RefSeq NM_001101
HUGO
OMIM
CCDS CCDS5341
HPRD 00032
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca