InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF1

Summary

InnateDB Gene

IDBG-76057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF1

Gene Name

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Synonyms

BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; N-TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII-250; TAFII250; XDP

Species

Homo sapiens

Ensembl Gene

ENSG00000147133

Encoded Proteins

IDBP-76059

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

IDBP-76061

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

IDBP-76063

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

IDBP-375452

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

IDBP-375491

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

IDBP-484606

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

IDBP-481495

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009]
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:71366239-71532374

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000373790	ENSP00000362895
ENST00000276072	ENSP00000276072
ENST00000373775	ENSP00000362880
ENST00000423759	ENSP00000406549
ENST00000437147	ENSP00000406517
ENST00000483365
ENST00000472567
ENST00000478305
ENST00000474917
ENST00000483985	ENSP00000424526
ENST00000463163	ENSP00000421611
ENST00000468167
ENST00000461764
ENST00000462588
ENST00000485087
ENST00000492404
ENST00000482544
ENST00000461157
ENST00000467309
ENST00000497222

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0017025	TBP-class protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0010467	gene expression
GO:0016032	viral process
GO:0016573	histone acetylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter