Version 5.4
Homo sapiens Gene: DDR1
Summary
InnateDB Gene IDBG-76157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDR1
Gene Name discoidin domain receptor tyrosine kinase 1
Synonyms CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
Species Homo sapiens
Ensembl Gene ENSG00000204580
Encoded Proteins
IDBP-76159
discoidin domain receptor tyrosine kinase 1
IDBP-76163
discoidin domain receptor tyrosine kinase 1
IDBP-76165
discoidin domain receptor tyrosine kinase 1
IDBP-76167
discoidin domain receptor tyrosine kinase 1
IDBP-76169
discoidin domain receptor tyrosine kinase 1
IDBP-76171
discoidin domain receptor tyrosine kinase 1
IDBP-237672
discoidin domain receptor tyrosine kinase 1
IDBP-364830
discoidin domain receptor tyrosine kinase 1
IDBP-369877
discoidin domain receptor tyrosine kinase 1
IDBP-369905
discoidin domain receptor tyrosine kinase 1
IDBP-369922
discoidin domain receptor tyrosine kinase 1
IDBP-369928
discoidin domain receptor tyrosine kinase 1
IDBP-369932
discoidin domain receptor tyrosine kinase 1
IDBP-369945
discoidin domain receptor tyrosine kinase 1
IDBP-369965
discoidin domain receptor tyrosine kinase 1
IDBP-369967
discoidin domain receptor tyrosine kinase 1
IDBP-369968
discoidin domain receptor tyrosine kinase 1
IDBP-478975
discoidin domain receptor tyrosine kinase 1
IDBP-478807
discoidin domain receptor tyrosine kinase 1
IDBP-478709
discoidin domain receptor tyrosine kinase 1
IDBP-483635
discoidin domain receptor tyrosine kinase 1
IDBP-473426
discoidin domain receptor tyrosine kinase 1
IDBP-479183
discoidin domain receptor tyrosine kinase 1
IDBP-484379
discoidin domain receptor tyrosine kinase 1
IDBP-482061
discoidin domain receptor tyrosine kinase 1
IDBP-479833
discoidin domain receptor tyrosine kinase 1
IDBP-481648
discoidin domain receptor tyrosine kinase 1
IDBP-473741
discoidin domain receptor tyrosine kinase 1
IDBP-477740
discoidin domain receptor tyrosine kinase 1
IDBP-484899
discoidin domain receptor tyrosine kinase 1
IDBP-484420
discoidin domain receptor tyrosine kinase 1
IDBP-485399
discoidin domain receptor tyrosine kinase 1
IDBP-480168
discoidin domain receptor tyrosine kinase 1
IDBP-480278
discoidin domain receptor tyrosine kinase 1
IDBP-484749
discoidin domain receptor tyrosine kinase 1
IDBP-476280
discoidin domain receptor tyrosine kinase 1
IDBP-478875
discoidin domain receptor tyrosine kinase 1
IDBP-482170
discoidin domain receptor tyrosine kinase 1
IDBP-482503
discoidin domain receptor tyrosine kinase 1
IDBP-475127
discoidin domain receptor tyrosine kinase 1
IDBP-483445
discoidin domain receptor tyrosine kinase 1
IDBP-476005
discoidin domain receptor tyrosine kinase 1
IDBP-484373
discoidin domain receptor tyrosine kinase 1
IDBP-473367
discoidin domain receptor tyrosine kinase 1
IDBP-477419
discoidin domain receptor tyrosine kinase 1
IDBP-475300
discoidin domain receptor tyrosine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30876421-30900156
Strand Forward strand
Band p21.33
Transcripts
ENST00000324771 ENSP00000318217
ENST00000376575 ENSP00000365759
ENST00000376568 ENSP00000365752
ENST00000376570 ENSP00000365754
ENST00000376569 ENSP00000365753
ENST00000376567 ENSP00000365751
ENST00000396342 ENSP00000379631
ENST00000424544 ENSP00000409400
ENST00000437124 ENSP00000394273
ENST00000446312 ENSP00000405998
ENST00000428153 ENSP00000390593
ENST00000412274 ENSP00000392413
ENST00000452441 ENSP00000405039
ENST00000421124 ENSP00000409682
ENST00000431373
ENST00000454612 ENSP00000406091
ENST00000417521 ENSP00000398682
ENST00000418800 ENSP00000407699
ENST00000502955 ENSP00000424346
ENST00000505066 ENSP00000421189
ENST00000460944 ENSP00000426420
ENST00000505534 ENSP00000420833
ENST00000513749 ENSP00000421753
ENST00000503180 ENSP00000424468
ENST00000508317 ENSP00000427369
ENST00000482050
ENST00000509639 ENSP00000422331
ENST00000515529
ENST00000507901 ENSP00000424703
ENST00000507046 ENSP00000425713
ENST00000504651 ENSP00000424758
ENST00000512694 ENSP00000426229
ENST00000503628 ENSP00000426799
ENST00000515233 ENSP00000422467
ENST00000506573
ENST00000515881 ENSP00000423492
ENST00000513043 ENSP00000423928
ENST00000511510 ENSP00000425113
ENST00000504927 ENSP00000427597
ENST00000513243
ENST00000515219 ENSP00000421152
ENST00000482873 ENSP00000421978
ENST00000504152
ENST00000508312 ENSP00000422442
ENST00000512336 ENSP00000421719
ENST00000512725 ENSP00000422108
ENST00000504679 ENSP00000423906
ENST00000503495 ENSP00000423749
ENST00000503670 ENSP00000422974
ENST00000513240 ENSP00000427552
ENST00000508472
ENST00000507533
ENST00000485023
ENST00000514534
ENST00000465966
ENST00000513514
ENST00000514434 ENSP00000427124
ENST00000484556 ENSP00000424003
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0038062 protein tyrosine kinase collagen receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001952 regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007566 embryo implantation
GO:0007595 lactation
GO:0008285 negative regulation of cell proliferation
GO:0010715 regulation of extracellular matrix disassembly
GO:0014909 smooth muscle cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030198 extracellular matrix organization
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043583 ear development
GO:0044319 wound healing, spreading of cells
GO:0046777 protein autophosphorylation
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060749 mammary gland alveolus development
GO:0061302 smooth muscle cell-matrix adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003534
View Gene Order
ENSBTAG00000010682
Not yet available
Pathways
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631988 Hs.739208
RefSeq NM_001202521 NM_001202522 NM_001202523 NM_001297652 NM_001297653 NM_001954 NM_013993 NM_013994 XM_006715186 XM_006715190 XM_006725502 XM_006725716 XM_006725717 XM_006725720 XM_006725828 XM_006725832 XM_006726018 XM_006726022
HUGO
OMIM
CCDS CCDS34385 CCDS4690 CCDS47396 CCDS56411 CCDS75419
HPRD 02678
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca