Homo sapiens Gene: DDX21 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-76283.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | DDX21 | ||||||||||||||||||||||
Gene Name | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | ||||||||||||||||||||||
Synonyms | GUA; GURDB; RH-II/GU; RH-II/GuA | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000165732 | ||||||||||||||||||||||
Encoded Proteins |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
DDX21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DHX36 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Ddx21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Dhx36 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.
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Entrez Gene | |||||||||||||||||||||||
Summary |
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:68956128-68985073 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q22.1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | Q8NI92 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 9188 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001256910 NM_004728 | ||||||||||||||||||||||
HUGO | HGNC:2744 | ||||||||||||||||||||||
OMIM | 606357 | ||||||||||||||||||||||
CCDS | CCDS73144 CCDS31211 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB062394 | ||||||||||||||||||||||
GenPept | BAB93481 | ||||||||||||||||||||||
RNA Seq Atlas | 9188 | ||||||||||||||||||||||